#213 Hypertension First-Line Medications Troubleshooting | Bread & Butter Series

Why can lower-dose combinations be more effective and better tolerated than maximizing one medication? How to troubleshoot common challenges such as amlodipine edema, gout, electrolyte abnormalities, and the patient who says they cannot tolerate anything? Why ACT (ARBs, Calcium Channel Blockers, Thiazides) is the preferred first-line framework, and how to personalize medication choices based on comorbidities and side effects.

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🔹Transcript and Shownotes

00:48 | Diagnosing Hypertension 

02:00 | When to Start Combination Therapy Instead of Monotherapy 

03:40 | Choosing First-Line Therapy Using the ACT Framework 

11:03 | Why ARBs Are Often Preferred Over ACE Inhibitors 

13:52 | Choosing the Right ARB: Candesartan vs Losartan 

16:19 | Comparing Potency & Duration Across First-Line Antihypertensives 

18:44 | Amlodipine Edema: Why It Happens and How to Fix It 

21:54 | Thiazides: Practical Tips, Electrolyte Problems & Class-Killer Side Effects 

27:33 | Managing Patients Who 'Can't Tolerate' Blood Pressure Medications 

Tags: Hypertension Management, High Blood Pressure, Primary Care, Internal Medicine, Core IM

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