Today’s episode of The Drive is a rebroadcast of the conversation with Rick Johnson (originally released January 6th, 2020). This episode was one of the most popular discussions to-date and is a prelude to an upcoming follow-up discussion which will be coming out in February 2022 along with the release of Rick’s new book.
In this episode, Rick Johnson, professor of nephrology at the University of Colorado, explains how his research into the causes of blood pressure resulted in a change of research direction to focus more on how fructose has such profound metabolic effects. Rick begins by talking about the relationship between salt and high blood pressure, then provides a masterclass into uric acid, and then expertly reveals the mechanisms and pathways by which sugar (specifically fructose) can profoundly impact metabolic health. From there, he explains how he applies this information to real life patients as well as touches on some of the most promising ideas around pharmacotherapy that are being developed in response to the epidemics of fatty liver, insulin resistance, diabetes, and obesity. Furthermore, Rick gives his take on artificial sweeteners compared to real sugar, discusses cancer’s affinity for fructose, and much more.
We discuss:
#157 - AMA #22: Losing fat and gaining fat: the lessons of fat flux
#156 - Jake Muise: Humanely harvesting axis deer while alleviating its impact on Hawaii’s vulnerable ecosystems
#155 - Chris Sonnenday, M.D.: The history, challenges, and gift of organ transplantation
#154 - Steve Levitt, Ph.D.: A rogue economist’s view on climate change, mental health, the ethics of experiments, and more
#153 - AMA #21: Deep dive into olive oil, high-intensity exercise, book update, and more
#152 - Michael Rintala, D.C.: Principles of Dynamic Neuromuscular Stabilization (DNS)
#151 - Alex Hutchinson, Ph.D.: Translating the science of endurance and extreme human performance
#150 - Senator Bill Frist, M.D.: A modern Renaissance man's journey through science, politics, and business
#149 - AMA #20: Simplifying the complexities of insulin resistance: how it's measured, how it manifests in the muscle and liver, and what we can do about it
#148 - Richard Miller, M.D., Ph.D.: The gold standard for testing longevity drugs: the Interventions Testing Program
#147 - Hussein Yassine, M.D.: Deep dive into the “Alzheimer’s gene” (APOE), brain health, and omega-3s
#146 - Guy Winch, Ph.D.: Emotional first aid and how to treat psychological injuries
#145 - AMA #19: Deep dive on Zone 2 training, magnesium supplementation, and how to engage with your doctor
#144 - Phil Maffetone: Optimizing health and performance through maximal aerobic function
#143 - John Ioannidis, M.D., D.Sc.: Why most biomedical research is flawed, and how to improve it
#142 - Robert Abbott: The Bobby Knight story—a cautionary tale of unchecked anger, ego, and winning at all costs
#141 - AMA #18: Deep dive: sugar and sugar substitutes
#140 - Gerald Shulman, M.D., Ph.D.: A masterclass on insulin resistance—molecular mechanisms and clinical implications
#139 - Kristin Neff, Ph.D.: The power of self-compassion
#138 - Lauren Miller Rogen and Richard Isaacson, M.D.: Alzheimer’s disease prevention—patient and doctor perspectives
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