We discuss:
Gerald’s background and interest in metabolism and insulin resistance (4:30); Insulin resistance as a root cause of chronic disease (8:30); How Gerald uses NMR to see inside cells (12:00); Defining and diagnosing insulin resistance and type 2 diabetes (19:15); The role of lipids in insulin resistance (31:15); Confirmation of glucose transport as the root problem in lipid-induced insulin resistance (40:15); The role of exercise in protecting against insulin resistance and fatty liver (50:00); Insulin resistance in the liver (1:07:00); The evolutionary explanation for insulin resistance—an important tool for surviving starvation (1:17:15); The critical role of gluconeogenesis, and how it’s regulated by insulin (1:22:30); Inflammation and body fat as contributing factors to insulin resistance (1:32:15); Treatment approaches for fatty liver and insulin resistance, and an exciting new pharmacological approach (1:41:15); Metformin’s mechanism of action and its suitability as a longevity agent (1:58:15); More.Learn more: https://peterattiamd.com/
Show notes page for this episode: https://peterattiamd.com/geraldshulman
Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/
Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/
Connect with Peter on Facebook | Twitter | Instagram.
#136 - AMA #17: Body composition methods tour de force, insulin resistance, and Topo Chico
#135 - BJ Miller, M.D.: How understanding death leads to a better life
#134 - James O’Keefe, M.D.: Preventing cardiovascular disease and the risk of too much exercise.
#133 - Vinay Prasad, M.D., M.P.H: Hallmarks of successful cancer policy
#132 - AMA #16: Exploring hot and cold therapy
#131 - Beth Lewis: The Art of Stability: Learning about pain, mitigating injury, and moving better through life
#130 - Carol Tavris, Ph.D. & Elliot Aronson, Ph.D.: Recognizing and overcoming cognitive dissonance
#129 - Tom Dayspring, M.D.: The latest insights into cardiovascular disease and lipidology
#128 – Irene Davis, Ph.D.: The evolution of the foot, running injuries, and minimalist shoes
#127 - AMA #3 with sleep expert, Matthew Walker, Ph.D.: Fasting, gut health, blue light, caffeine, REM sleep, and more
#126 – Matthew Walker, Ph.D.: Sleep and immune function, chronotypes, hygiene tips, and addressing questions about his book
#125 - John Arnold: The most prolific philanthropist you may not have heard of
#124 - AMA #15: Real-world case studies—metabolic dysregulation, low testosterone, menopause, and more
#123 - Joan Mannick, M.D. & Nir Barzilai, M.D.: Rapamycin and metformin—longevity, immune enhancement, and COVID-19
#122 - Lori Gottlieb: Understanding pain, therapeutic breakthroughs, and keys to enduring emotional health
#121 - Azra Raza, M.D.: Why we're losing the war on cancer
#120 - AMA with Dom D’Agostino, Ph.D., Part II of II: Ketosis for cancer and chronic disease, hyperbaric oxygen therapy, and the effect of ketosis on female health
#119 - Terry Real: Breaking the cycle of shame, anger, and depression
#118 - Lloyd Klickstein, M.D., Ph.D.: Rapamycin, mTOR inhibition, and the biology of aging
#117 - Stanley Perlman, M.D., Ph.D.: Insights from a coronavirus expert on COVID-19
Create your
podcast in
minutes
It is Free
Good Mood Revolution
Huberman Lab
Good Nurse Bad Nurse
The Relaxback UK Show
On Call With Dr. Anselm Anyoha
The Doctor’s Farmacy with Mark Hyman, M.D.