64. LP(a): The Massively Important, But Totally Overlooked Biomarker of Heart Attacks, Strokes, and Heart Disease
Extend Podcast with Darshan Shah, MD

64. LP(a): The Massively Important, But Totally Overlooked Biomarker of Heart Attacks, Strokes, and Heart Disease

2025-05-22
In this episode of Extend, we're digging into one of the most dangerous—and most overlooked—drivers of heart disease: LP(a). You could have a clean lifestyle, normal labs, and still be at high risk for a heart attack or stroke. Why? Because LP(a) isn't included in standard cholesterol tests—and 1 in 5 people have elevated levels without knowing it. I break down what LP(a) actually is, why it's more inflammatory and damaging than LDL, and how it contributes to plaque, heart attacks, strokes, and valve disease. You'll learn why lifestyle changes don't lower it, what to do if your levels are high, and how cutting-edge RNA therapies could offer hope....
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