Targeting Senescent Cells? Dose and Timing Matters - with Dr. Greg Kelly

Get ready for a deep dive into the world of cellular senescence and its implications for aging. Dr. Greg Kelly joins me on New Frontiers to explain the science behind targeting this Hallmark of Aging and share natural compounds and activities that target cellular senescence. I am particularly excited for you to hear his thoughts around dosing and cyclical timing of exposure to senolytic compounds, such as fisetin, luteolin, quercetin, and piperlongumine, and why that may make the difference between having the effect you want... or not. Don't miss his advice on smart exercise tweaks for aging and the caution that overdoing it with exercise in our later years is much more harmful than it was in our twenties. Lots to unpack here. Enjoy! - DrKF Head over to https://www.drkarafitzgerald.com/fxmed-podcast/ for all the full transcription and all relevant links and resources. *Guest information* Dr. Greg Kelly is Senior Director of Product Development at Neurohacker Collective, naturopathic physician (N.D.), and author of the book Shape Shift. greg@neurohacker.com https://www.facebook.com/neurohackercollective https://www.instagram.com/neurohacker/ https://www.linkedin.com/in/gregory-kelly-98b96b138/ *Qualia Discount for New Frontiers Listeners* If you’re in your late 20’s or older, adding Qualia Senolytic to your diet can play a CRUCIAL role in combating negative aging symptoms. Go to https://tinyurl.com/3zpsaw3s for up to 50% off Qualia Senolytic and as a listener of New Frontiers podcast use code KARA at checkout for an extra 15% off your first purchase. *Show Notes* Dr. Gregory Kelly: https://neurohacker.com/people/greg-kelly Neurohacker Collective: https://tinyurl.com/3zpsaw3s Shape Shift: https://tinyurl.com/3zpsaw3s Alternative Medicine Review: https://tinyurl.com/56ad9av9 Textbook of Natural Medicine: https://tinyurl.com/56ad9av9 Qualia Studies: https://neurohacker.com/studies Inulin-Type Probiotics - A Review (Part 1 and 2): https://altmedrev.com/?s=inulin James Schmachtenberger: https://tinyurl.com/yjhkj8k9 Daniel Schmachtenberger: https://tinyurl.com/yz2da5r4 Quercefit: https://tinyurl.com/4646pu8p Study: The Hallmarks of Aging: https://tinyurl.com/5cdnnbuy Study: Hallmarks of aging: An expanding universe: https://tinyurl.com/2y8dtx27 The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs: https://tinyurl.com/3k2sxkrb The Clinical Potential of Senolytic Drugs: https://tinyurl.com/5xdy2kk9 Epigenetic clock analyses of cellular senescence and ageing: https://tinyurl.com/4vxany6p The relationship between epigenetic age and the hallmarks of aging in human cells: https://tinyurl.com/34m626a2 Qualia Mind: https://tinyurl.com/23xv42fj Vittorio Sebastiano: https://tinyurl.com/4md5xvxh *DrKF Resources* FxMed Blog: The 12 biological hallmarks of aging viewed through a functional medicine and functional longevity lens: https://tinyurl.com/5n6c5b84 Decoding Aging: The Science Of Cellular Rejuvenation With Dr. Vittorio Sebastiano: https://tinyurl.com/2z54h5h8 DrKF Patient consults with DrKF physicians including Younger You Concierge: https://www.drkarafitzgerald.com/our-clinic/our-services/ Bio Age Lab Test: https://youngeryouprogram.com/bio-age-lab-test/ Bio Age Self Assessment Quiz: https://youngeryouprogram.com/basa/ Younger You Group Program: https://www.drkarafitzgerald.com/younger-you-intensive-virtual-group/ Younger You book: https://youngeryouprogram.com/book/ Dr. Fitzgerald is actively engaged in award-winning clinical research on epigenetics and longevity using a diet and lifestyle intervention developed in her research and practice. She has published two clinical studies on the potential bioage-reversing effects of an 8-week DNA methylation-supportive diet and lifestyle in middle-aged men and women and is the author of the bestselling book Younger You: How to Reduce Your Bio Age and Live Longer, Better. Senolytic, Qualia, Senescent Cells, Qualia Senolytic