Increased Autoreactivity and Maturity of EBI2+ Antibody-Secreting Cells in Nasal Polyps: Implications for Recurrence and Treatment

In this episode of the Better Edge podcast, Bruce K. Tan, MD, associate professor of Otolaryngology – Head and Neck Surgery at Northwestern Medicine, discusses his recent research study titled, “Increased Autoreactivity and Maturity of EBI2+ Antibody-Secreting Cells from Nasal Polyps,” which sheds light on the cells’ role in predicting polyp recurrence after sinus surgery and the potential implications for diagnosing and treating nasal polyps. The findings also contribute to our understanding of immune response, antibodies and inflammation in respiratory conditions, highlighting the unique activation mechanisms and tissue-resident memory cells in the airway.