In this “Ask Me Anything” (AMA) episode, Peter and Bob discuss all things related to GLP-1 agonists—a class of drugs that are gaining popularity for the treatment of obesity. They cover the discovery of these peptides, their physiology, and what it is they do in their natural state. Next, Peter and Bob break down a recently published study which showed remarkable results for weight loss and other metabolic parameters using a once-weekly injection of the GLP-1 agonist drug semaglutide, also known as Ozempic, in overweight and obese patients. Finally, they compare results from the semaglutide study to results from various lifestyle interventions and give their take on the potential future of GLP-1 agonists.
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We discuss:
Earning the gift of life | Ric Elias (#79 rebroadcast)
#212 - The neuroscience of obesity | Stephan Guyenet, Ph.D.
#211 - AMA #36: Fruits & vegetables—everything you need to know
#210 - Lp(a) and its impact on heart disease | Benoît Arsenault, Ph.D.
#209 ‒ Medical mistakes, patient safety, and the RaDonda Vaught case | Marty Makary, M.D., M.P.H.
The Art of Stability | Beth Lewis (Ep. #131 Rebroadcast)
#208 - Tragedy, grief, healing, and finding happiness | Kelsey Chittick
#207 - AMA #35: "Anti-Aging" Drugs — NAD+, metformin, & rapamycin
#206 - Exercising for longevity: strength, stability, zone 2, zone 5, and more
#205 - Energy balance, nutrition, & building muscle | Layne Norton, Ph.D. (Pt.2)
#204 - Centenarians, metformin, and longevity | Nir Barzilai, M.D.
#203 - AMA #34: What Causes Heart Disease?
#202 - Peter on nutrition, disease prevention, sleep, and more — looking back on the last 100 episodes
In remembrance of Sarah Hallberg, D.O., M.S. (Ep. #162 Rebroadcast)
#201 - Deep dive back into Zone 2 | Iñigo San-Millán, Ph.D. (Pt. 2)
#200 - AMA #33: Hydration—electrolytes, supplements, sports drinks, performance effects, and more
#199 - Running, overcoming challenges, and finding success | Ryan Hall
#198 - Eye health—everything you need to know | Steven Dell, M.D.
#197 - The science of obesity & how to improve nutritional epidemiology | David Allison, Ph.D.
#196 - AMA #32: Exercise, squats, deadlifts, BFR, and TRT
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