In this episode, Eileen White, Chief Scientific Officer at the Rutgers Cancer Institute, describes the fundamental role of autophagy in the maintenance of health and prevention of neurodegeneration, cancer, and other diseases. She also goes into detail about the paradoxical finding that autophagy may benefit an existing cancer cell and help it to survive—a discovery leading to new possibilities in cancer therapy. We also discuss fasting (and molecules that induce autophagy) and the critical need to decode the proper fasting “dose” in order to improve human health.
We discuss:
Eileen’s discovery that a specific oncogene blocks apoptosis [3:40]; Defining apoptosis and its role in cancer prevention [10:00]; How cancer cells use the autophagy pathway to survive [17:20]; Stressors that induce autophagy [29:15]; The importance of autophagy in the brain and liver [32:45]; The mechanisms that can trigger autophagy to support longevity [40:00]; Evidence for cancer treatment by blocking autophagy [42:30]; Types of cancer that are most autophagy-dependent [46:45]; The autophagy paradox [52:40]; Finding a molecular signal for autophagy [59:15]; Current knowledge gaps around fasting as a tool for longevity [1:13:00]; Rapamycin, metformin, and other molecules that may induce autophagy [1:22:15]; How to study fasting and exercise as longevity tools [1:32:50]; The Nobel Prize for autophagy research [1:36:45]; Eileen’s future areas of research [1:38:25]; A fasting strategy for Alzheimer’s Disease prevention[1:49:25]; Future study of metabolism and autophagy [1:51:30]; and More.
Learn more: https://peterattiamd.com/
Show notes page for this episode: https://peterattiamd.com/eileenwhite
Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/
Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/
Connect with Peter on Facebook | Twitter | Instagram.
#249 ‒ How the brain works, Andrew’s fascinating backstory, improving scientific literacy, and more | Andrew Huberman, Ph.D.
#248 ‒ OUTLIVE book: A behind-the-scenes look into the writing of this book, motivation, main themes, and more
#247 ‒ Preventing cardiovascular disease: the latest in diagnostic imaging, blood pressure, metabolic health, and more | Ethan Weiss, M.D.
#246 - AMA #45: Pros and cons of GLP-1 weight loss drugs and metformin as a geroprotective agent
#245 ‒ Overcoming trauma, finding inner peace, and living a meaningful and fulfilling life | Lewis Howes
#244 ‒ The history of the cell, cell therapy, gene therapy, and more | Siddhartha Mukherjee
#243 ‒ The fentanyl crisis and why everyone should be paying attention | Anthony Hipolito
#242 - AMA #44: Peter’s historical changes in body composition with his evolving dietary, fasting, and training protocols
#241 ‒ Living intentionally, valuing time, prioritizing relationships, and more keys to a rich life | Ric Elias (Part 2)
#240 ‒ The confusion around HDL and its link to cardiovascular disease | Dan Rader, M.D.
#239 ‒ The science of strength, muscle, and training for longevity | Andy Galpin, Ph.D. (PART I)
#238 – AMA #43: Understanding apoB, LDL-C, Lp(a), and insulin as risk factors for cardiovascular disease
#237 ‒ Optimizing life for maximum fulfillment | Bill Perkins
#236 ‒ Neurodegenerative disease: pathology, screening, and prevention | Kellyann Niotis, M.D.
James Clear: Building & Changing Habits (#183 rebroadcast)
#235 ‒ Training principles for mass and strength, changing views on nutrition, creatine supplementation, and more | Layne Norton, Ph.D.
#234 ‒ Chris Hemsworth on Limitless, longevity, and happiness
#233 - AMA #42: Optimizing sleep - bedtime routine, molecule regimen, sleep trackers, sauna, & more
#232 ‒ Shoulder, elbow, wrist, and hand: diagnosis, treatment, and surgery of the upper extremities | Alton Barron, M.D.
A masterclass on insulin resistance—mechanisms and implications | Gerald Shulman, M.D., Ph.D. (#140 rebroadcast)
Create your
podcast in
minutes
It is Free
Good Mood Revolution
Huberman Lab
Good Nurse Bad Nurse
The Relaxback UK Show
On Call With Dr. Anselm Anyoha
The Doctor’s Farmacy with Mark Hyman, M.D.