In this Episode of the Epigenetics Podcast our guest Ana Pombo from the Max-Delbrück-Center in Berlin provides insight in her work on the interplay between gene regulation and genome architecture. To do so she and her team use different state of the art methods, including cryo-sectioning to unravel this regulatory network. In 2006, they proposed the Interchromatin Network Model of chromosome organization which postulates that chromosome folding is driven by contacts between different genomic regions and between chromatin and nuclear landmarks, such as the nuclear lamina. And later on they used polymer physics modeling to study those mechanisms, which lead to the development of the Strings & Binders Switch (SBS) model. And this is just a glimpse of the topics that are discussed in this Episode.
References
Contact
When is a Peak a Peak? (Claudio Cantù)
Analysis of 3D Chromatin Structure Using Super-Resolution Imaging (Alistair Boettiger)
Gene Dosage Alterations in Evolution and Ageing (Claudia Keller Valsecchi)
Structural Analysis of Nucleosomes During Transcription (Lucas Farnung)
DNA Methylation Alterations in Neurodegenerative Diseases (Paula Desplats)
scDamID, EpiDamID and Lamina Associated Domains (Jop Kind)
Circulating Epigenetic Biomarkers in Cancer (Charlotte Proudhon)
Epigenetic Landscapes During Cancer (Luciano Di Croce)
Formation of CenH3-deficient Kinetochores (Ines Drinnenberg)
Effects of Environmental Cues on the Epigenome and Longevity (Paul Shiels)
The Epigenetics of Human Sperm Cells (Sarah Kimmins)
Transgenerational Inheritance and Evolution of Epimutations (Peter Sarkies)
Transcription Elongation Control by the Paf1 Complex (Karen Arndt)
Molecular Mechanisms of Chromatin Modifying Enzymes (Karim-Jean Armache)
The Role of PHF13 in Chromatin and Transcription (Sarah Kinkley)
Genome Organization Mediated by RNA Polymerase II (Argyrys Papantonis)
The Role of Pioneer Factors Zelda and Grainyhead at the Maternal-to-Zygotic Transition (Melissa Harrison)
Epigenetics in Human Malaria Parasites (Elena Gómez-Diaz)
Bioinformatic Analysis in Epigenetics Research (Nick Pervolarakis)
Anchor-Based Bisulfite Sequencing (Ben Delatte)
Create your
podcast in
minutes
It is Free
DNA Today: A Genetics Podcast
Museum of the Missing
Strange by Nature Podcast
Sasquatch Chronicles
Hidden Brain