In this episode of the Epigenetics Podcast, we sat down with Marcus Buschbeck, Group Leader at the Josep Carreras Leukaemia Research Institute in Barcelona, to talk about his work on the histone variant macroH2A, its role in metabolism and how it contributes to the regulation of chromatin structure.
Histone variants equip chromatin with unique properties and show a specific genomic distribution. The histone variant macroH2A is unique in having a tripartite structure consisting of a N-terminal histone-fold, an intrinsically unstructured linker domain and a C-terminal macro domain. Recent discoveries show that macroH2A proteins have a major role in the nuclear organization which has the potential to explain how these proteins can act as tumor suppressors, promoters of differentiation and barriers to somatic cell reprogramming.
We discuss these topics, the mission of the Josep Carreras Leukaemia Research Institute, and much more in this episode.
References
Contact
Transgenerational Inheritance and Epigenetic Imprinting in Plants (Mary Gehring)
When is a Peak a Peak? (Claudio Cantù)
Analysis of 3D Chromatin Structure Using Super-Resolution Imaging (Alistair Boettiger)
Gene Dosage Alterations in Evolution and Ageing (Claudia Keller Valsecchi)
Structural Analysis of Nucleosomes During Transcription (Lucas Farnung)
DNA Methylation Alterations in Neurodegenerative Diseases (Paula Desplats)
scDamID, EpiDamID and Lamina Associated Domains (Jop Kind)
Circulating Epigenetic Biomarkers in Cancer (Charlotte Proudhon)
Epigenetic Landscapes During Cancer (Luciano Di Croce)
Formation of CenH3-deficient Kinetochores (Ines Drinnenberg)
Effects of Environmental Cues on the Epigenome and Longevity (Paul Shiels)
The Epigenetics of Human Sperm Cells (Sarah Kimmins)
Transgenerational Inheritance and Evolution of Epimutations (Peter Sarkies)
Transcription Elongation Control by the Paf1 Complex (Karen Arndt)
Molecular Mechanisms of Chromatin Modifying Enzymes (Karim-Jean Armache)
The Role of PHF13 in Chromatin and Transcription (Sarah Kinkley)
Genome Organization Mediated by RNA Polymerase II (Argyrys Papantonis)
The Role of Pioneer Factors Zelda and Grainyhead at the Maternal-to-Zygotic Transition (Melissa Harrison)
Epigenetics in Human Malaria Parasites (Elena Gómez-Diaz)
Bioinformatic Analysis in Epigenetics Research (Nick Pervolarakis)
Create your
podcast in
minutes
It is Free
DNA Today: A Genetics Podcast
Museum of the Missing
Strange by Nature Podcast
Sasquatch Chronicles
Hidden Brain