Interleukin-2 therapies have been seen as promising ways to treat solid tumors, but they have proven challenging because of the ability of IL-2 to both activate and suppress the immune system. Their effectiveness has been limited because of potentially toxic side effects, which have included vascular leak syndrome and pulmonary edema. Aulos Biosciences believes the AI-based approach to computational drug design used for its lead experimental therapy allows it to unlock the power of IL-2 without triggering the concerning side effects of existing therapies. We spoke to Aron Knickerbocker, president and CEO of Aulos Bioscience, about the potential for IL-2 therapies to treat solid tumors, the limits of today's IL-2 therapies, and the AI-based design behind its experimental IL-2 therapy in development.
Treating Aging-Related Disease by Targeting Molecular Drivers of Aging
Engineering Better Cell Therapies for Cancers
Targeting a Regulator of Inflammation to Treat Alzheimer’s Disease
Enabling Regenerative Therapies without Immunosuppression
Making Vaccine and Biotherapeutic Production Fast and Affordable
Forcing Cancers to Reveal Themselves
Making Clinical Trials Diverse and Accessible
Mining Bugs for Drugs
A Company That Bets Its Therapies Will Click with Patients
A Company Where It takes Guts and Brains to Develop Drugs
Changing Outcomes with Data
Treating Psychiatric Conditions with Tripless Psychedelics
How AI Is Finding Its Way into Unexpected Places in Biopharma Companies
Searching the Dark Matter of the Proteome to Develop New Therapies
The Year in Biotech and What’s Ahead in 2023
Targeting a Novel Checkpoint to Treat Cancer and Autoimmune Conditions
The Growing Need for Biosecurity Vigilance
Enlisting Next-Generation Cytokine Immunotherapies in the Fight Against Cancer
Engineering Safer and More Effective Cell Therapies
Changing Drug Discovery for Neuropsychiatric Disorders with Phenotypic Screens
Create your
podcast in
minutes
It is Free
DNA Today: A Genetics Podcast
Short Wave
Unexplainable
Speaking of Psychology
Stuff To Blow Your Mind