The JAK-STAT pathway plays a pivotal role in the pathogenesis of myeloproliferative neoplasms (MPNs) including polycythemia vera, essential thrombocythemia, and myelofibrosis and JAK 1/2 inhibitors such as ruxolitinib have been vital in improving patient survival. The recent approval of ropeginterferon, an interferon therapy for patients with polycythemia vera, and investigational combination therapies in myelofibrosis represent a new generation of therapies that aim to treat MPNs.
In this podcase, Ruben Mesa, MD, UT Health San Antonio MD Anderson Cancer Center, San Antonio, TX, and Naveen Pemmaraju, MD, University of Texas MD Anderson Cancer Center, Houston, TX, share valuable insights on MPNs, including the use of LSD1 inhibitor IMG7289 and ropeginterferon in the second line setting, as well as updates in the treatment landscape of polycythemia vera and myelofibrosis. This interview took place at the 63rd ASH Annual Meeting and Exposition Congress, Atlanta, GA, 2021.
EHA 2021: updates on novel agents for AML
Texas MPN Workshop 2021: updates on JAK inhibitors for MPNs
EHA 2021: targeted therapies for ALL
Texas MPN Workshop 2021: updates on interferons for MPNs
EHA 2021: real-world data on myeloma, lymphoma and CLL
Novel BTK inhibitors for NHL
Latest updates on T-cell therapies for non-Hodgkin lymphoma
Novel CD20/CD3 bispecific antibodies in NHL
Latest updates on CAR-T therapy for lymphoma
EHA & ICML 2021: updates in Hodgkin lymphoma
Latest transplant updates from EHA 2021
Key updates on CAR-T therapy for multiple myeloma
The Lymphoma Sessions: highlights from EHA and ICML 2021
The CLL Sessions: highlights from EHA and ICML 2021
EHA 2021: updates on treatment for MDS
iwNHL 2021: immunotherapy and the microenvironment
The Myeloma Sessions: highlights from EHA and ASCO 2021
EHA 2021: key trial updates in myelofibrosis
The MPN Sessions: highlights from EHA and ASCO 2021
The MDS Sessions: highlights from ASCO/EHA 2021
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