Is there any hope for the US / Iranian relationship?

Few nations have as long a history of uninterrupted conflict and misunderstanding as the United States and Iran.  The markers along that road are tall.  The US coup that installed the Shah, the hostage crisis, Khobar towers, Lebanon, holocaust denial and the continually failed US efforts to seize opportunities when presented by Iran, have all contributed.

The issue of US/Iranian relations have run through the center of American foreign policy for the past 60 years, through ten successive administrations, Republican and Democrat alike.

Yet with each successive effort or treatment, the disease always threatens to burst out and become full blown. This is where we are once again, in the nuclear talks in Vienna, and in an effort to stabilize Iraq and Syria.  

Are we at a new critical point in this relationship or is it all just another failed effort at rapprochement? Long time Iranian diplomat and now a Professor at Princeton, Seyed Hossein Mousavian thinks there is reason for optimism. He makes his case in Iran and The United States: An Insider's View on the Failed Past and the Road to Peace.

My conversation with Seyed Hossein Mousavian: