Episode 504 - Looking inside living cells with Bioorthogonal chemistry

A big prize like the Nobel for Chemistry doesn't appear out of nowhere. To win a Nobel Prize, a lot of team work in laboratories and across the world has to come together. We find out about the research that led towards the Nobel Prize for chemistry and how it grew. How does Click Chemistry solve the problem of messy and complicated reactions? How do you look inside a cell when it's working without destroying it? How can you get precise tracking of cells behavior using Bioorthogonal chemistry.

1. Castelvecchi, D. and Ledford, H., 2022. Chemists who invented revolutionary ‘click’ reactions win Nobel. [online] Nature.com. Available at: [Accessed 8 October 2022].
2. Ramström, O., 2022. CLICK CHEMISTRY A N D BIOORTHOGONAL CHEMISTRY. [online] Nobelprize.org. Available at: [Accessed 8 October 2022].
3. Zhang, H., 2022. Nobel Prize: How click chemistry and bioorthogonal chemistry are transforming the pharmaceutical and material industries. [online] The Conversation. Available at: [Accessed 8 October 2022].