Episode 517 - How our body senses and interacts with the world

Understanding how our body senses and interacts with the world. Scientists are only now beginning to understand how our body senses the world, hence the '21 Nobel Prizes. This Nobel prize wining research helped others find a connection between the gut and our sense of touch. Internal organ pain can be crippling and require side effect laden treatments. How do organs like the gut detect and transmit pain signals? The same mechanism to detect soft touch is used by your organs to send pain signals. How does our body precisely control temperature? What region of the brain measures and control what temperature to set itself to?

1. Zili Xie, Jing Feng, Timothy J. Hibberd, Bao Nan Chen, Yonghui Zhao, Kaikai Zang, Xueming Hu, Xingliang Yang, Lvyi Chen, Simon J. Brookes, Nick J. Spencer, Hongzhen Hu. Piezo2 channels expressed by colon-innervating TRPV1-lineage neurons mediate visceral mechanical hypersensitivity. Neuron, 2022; DOI: 10.1016/j.neuron.2022.11.015
2. Yoshiko Nakamura, Takaki Yahiro, Akihiro Fukushima, Naoya Kataoka, Hiroyuki Hioki, Kazuhiro Nakamura. Prostaglandin EP3 receptor–expressing preoptic neurons bidirectionally control body temperature via tonic GABAergic signaling. Science Advances, 2022; 8 (51) DOI: 10.1126/sciadv.add5463