”Got Guts” The Micro Version: Colon ion transporter gene expression during cirrhosis

Diego Alvarez de la Rosa of the University of La Laguna discusses the recently published manuscript titled “Decaying kidney function during cirrhosis correlates with remodeling of distal colon aldosterone target gene expression.”

 

NEW & NOTEWORTHY Liver cirrhosis progression significantly alters ion transporter subunit expression in the rat distal colon, a change that correlated well with declining kidney function and the severity of the disease. Natalia Serrano-Morillas et al. data suggests that the steroid hormone aldosterone participates in this homeostatic response to maintain electrolyte balance.

 

Article Citation:

Decaying kidney function during cirrhosis correlates with remodeling of distal colon aldosterone target gene expression

Natalia Serrano-Morillas, Carlos González-Alayón, Arianna Vastola-Mascolo, Ana E. Rodríguez-Rodríguez, Guadalberto Hernández, Esteban Porrini, Manuel Hernández-Guerra, and Diego Alvarez de la Rosa

American Journal of Physiology-Gastrointestinal and Liver Physiology 2023 325:4, G306-G317