JNP Micro Podcasts: Inhibitory Synaptic Transmission in the Kölliker-Fuse of Rett Syndrome mice

In this episode of JNP's micro podcasts, Jessica R. Whitaker-Fornek of the University of Michigan Medical School discusses the recently published research titled "Inhibitory synaptic transmission is impaired in the Kölliker-Fuse of male, but not female, Rett syndrome mice." 

NEW & NOTEWORTHY Kölliker-Fuse (KF) neurons in acute brain slices from male Rett syndrome (RTT) mice receive reduced inhibitory synaptic inputs compared with wild-type littermates. In female RTT mice, inhibitory transmission was not different in KF neurons compared with controls. The results from this study show that sex-specific alterations in synaptic transmission occur in the KF of RTT mice.

 

Inhibitory synaptic transmission is impaired in the Kölliker-Fuse of male, but not female, Rett syndrome mice

Jessica R. Whitaker-Fornek, Paul M. Jenkins, and Erica S. Levitt

Journal of Neurophysiology 2023 130:6, 1578-1587