Mitochondrial Dynamics Impact Endothelial Function

What role does mitochondrial fragmentation play in endothelial dysfunction under conditions of low glucose? Listen as Consulting Editor Michael Wolin (New York Medical College) interviews lead author Michael Widlansky (Medical College of Wisconsin) and content expert Prasad Katakam (Tulane University School of Medicine) about the new work by Tanner et al which investigated the often-overlooked condition of low glucose in humans. Does the mitochondrial fission protein dynamin-related protein 1 (DRP1) regulate vascular endothelial function through ROS production? Our experts explore the work by Widlansky and colleagues that leads to new and engaging open questions. How is DRP1 activated and what docking proteins may be involved? Listen and find out.

 

Michael John Tanner, Jingli Wang, Rong Ying, Tisha B Suboc, Mobin Malik, Allison Couillard, Amberly Branum, Venkata Puppala, Michael Eric Widlansky Dynamin-Related Protein 1 Mediates Low Glucose-Induced Endothelial Dysfunction in Human Arterioles Am J Physiol Heart Circ Physiol, published online December 6, 2016. DOI: 10.1152/ajpheart.00499.2016