Resveratrol and Exercise Capacity in Heart Failure

Does resveratrol positively impact exercise intolerance in heart failure patients? Listen as Associate Editor Christine Des Rosiers (Universite de Montreal) interviews lead author Jason Dyck (University of Alberta) and content expert Yan Burelle (University of Ottawa) about the exciting new study by Sung et al, which used a mouse model of heart failure to determine if treatment with resveratrol restored exercise tolerance to normal levels. Dyck and co-authors clearly show that resveratrol is effective as a treatment for exercise intolerance in heart failure, not solely as a preventative strategy, and this may have important clinical implications for human heart failure patients. What role does the gut microbiome play in this resveratrol treatment study, and what cautionary words do these experts have about equating nutraceutical resveratrol treatment with the naturally occurring polyphenol resveratrol commonly found in red wine? Listen and find out.

 

Miranda M. Sung, Nikole J Byrne, Ian M Robertson, Ty T Kim, Victor Samokhvalov, Jody Levasseur, Carrie-Lynn M Soltys, David Fung, Neil Tyreman, Emmanuel Denou, Kelvin Jones, John M Seubert, Jonathan D. Schertzer, Jason R.B. Dyck Resveratrol improves exercise performance and skeletal muscle oxidative capacity in heart failure Am J Physiol Heart Circ Physiol, published April 1, 2017. DOI: 10.1152/ajpheart.00455.2016