A most curious question, so thank you for this one! Here is my extensive research into this very topical question and the result of my findings.
Research articles referred to:
https://jamanetwork.com/journals/jama/fullarticle/194127
https://www.sciencedirect.com/science/article/pii/S0140673610608884
https://ascpt.onlinelibrary.wiley.com/doi/abs/10.1038/clpt.1985.197
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