Podbean logo
  • Discover
  • Podcast Features

    Your all-in-one podcasting solution.

    Podcast App

    The best podcast player & podcast app.

  • Livestream

    High-performing audio live, without limits.

    Podcast Studio

    Easy-to-use audio recorder app.

  • PodAds

    Dynamic Ad Insertion for podcasts.

  • Premium

    Convert listeners into buyers anywhere, anytime
    with the convenience of Podbean Premium.

    Patron

    The seamless way for fans to support you directly
    from your podcast.

  • Ads Marketplace

    Join Ads Marketplace to earn money
    through sponsorship on your podcast.

  •  
  • All Arts Business Comedy Education
  • Fiction Government Health & Fitness History Kids & Family
  • Leisure Music News Religion & Spirituality Science
  • Society & Culture Sports Technology True Crime TV & Film
  • Live
  • Log in
  • Start your podcast for free
  • Podcasting
    • Podcast Features
    • Live Stream
    • PodAds
    • Podcast App
    • Podcast Studio
  • Monetization
    • Premium
    • Patron
    • Ads Marketplace
  • Enterprise
  • Pricing
  • Discover
  • Log in
    Sign up free
Laboratory Considerations for Clinical Trials

Laboratory Considerations for Clinical Trials

Science:Life Sciences

Monitoring the Tumor Micro-environment with Flow Cytometry - Mark Edinger

Monitoring the Tumor Micro-environment with Flow Cytometry - Mark Edinger

2019-03-05
Download

Mark Edinger is the Scientific Advisor for Flow Cytometry at Q2 Solutions. In this episode, he describes recent advances in flow cytometry and what that means for immuno-oncology trials.

New instruments, reagents and software are enabling researchers to monitor 30-some markers simultaneously to get a better picture of the tumor micro-environment and the interactions taking place.

For example, there's a whole list of new checkpoint inhibitors, like PD-1, CTLA-4, CD-1-52 and a multitude of other CD-47 that have been described, and their ligands on T cells and immune cells, not just T cells, that allows the tumor to actively turn off the host response to the tumor that prevent the tumor from being killed by the immune system. We weren't aware of these, many of these, until we had the tools that allow us to look at many more markers simultaneously. For instance markers of T cell activation have been around for a long time, but that list has expanded remarkably now, and the lists of markers of T cell exhaustion have really expanded as well, and some of those were not discovered until relatively recently, in the last 5 or 6 years.

Mark explained how flow cytometry is being used to determine whether a therapeutic is efficacious or not and the benefits that flow to the patient.

He stressed, as others in this series have, the importance of early engagement between sponsors and their clinical trials partners. Regular phone calls and direct conversations between scientists help refine the assays to produce the desired result in terms of the information collected from a panel.

 

view more

More Episodes

Flexible Approaches for Biotech Companies in Clinical Trials
2022-06-22 30
Risk Management for Biotech Companies in Clinical Trials
2022-05-16 68
3 Things to Consider in Preparation for Your Biotech Testing or Trial
2022-04-07 109
Hybrid assays: an interview with Barry Jones and Adriane Spytko
2022-03-17 80
Managing Sample Data from Vendors
2021-09-15 156
Automation within an ADME Laboratory
2021-08-26 157
Bioanalytical Automation of Samples
2021-07-30 117
Consent Tracking for Clinical Samples
2021-07-28 130
Tracking Clinical Trial Samples
2021-07-28 121
Avoiding Canceled Tests in Pediatric Samples
2021-02-02 128
Covid Vaccine Testing
2020-09-15 170
Hybrid Assays for Protein Bioanalysis
2020-07-29 126
High Throughput ADME Testing
2020-07-29 80
Liquid Biopsy Collection in Clinical Development Programs
2020-07-29 104
An Next Generation Sequencing Approach to Influenza Vaccine Development
2019-10-25 202
Standardization of Tumor Mutational Burden by Alignment to Reference Standards
2019-10-25 65
Companion Diagnostic Strategies for Commercial Success
2019-02-26 138
The Role of Genomics in Clinical Trials for Immuno-oncology - Dr. Patrick Hurban
2019-02-19 108
Bioanalysis for Immuno-oncology - Dr. Mike Brown
2019-02-12 68
  • ←
  • 1
  • 2
  • →
0123456789101112131415171819

Get this podcast on your
phone, FREE

Download Podbean app on App Store Download Podbean app on Google Play

Create your
podcast in
minutes

  • Full-featured podcast site
  • Unlimited storage and bandwidth
  • Comprehensive podcast stats
  • Integrate with iTunes and Google
    store
  • Make money with your podcast
Get started

It is Free

  • Podcast Services

    • Podcast Features
    • Pricing
    • Enterprise Solution
    • Private Podcast
    • The Podcast App
    • Live Stream
    • Audio Recorder
    • Remote Recording
  •  
    • Create a Podcast
    • Video Podcast
    • Start Podcasting
    • Start Radio Talk Show
    • Education Podcast
    • Switch to Podbean
    • Submit Your Podcast
    • Podbean Plugins
  •  
    • Church Podcast
    • Nonprofit Podcast
    • Get Sermons Online
    • Free Audiobooks
    • How to Start a Podcast
    • How to Start a Live Podcast
    • How to Monetize a podcast
    • How to Promote Your Podcast
    • How to Use Group Recording
  • MONETIZATION

    • Premium Podcast
    • Podcast Advertising
    • Patron Program
  • Support

    • Contact Us
    • Support Center
    • Developers
    • Resources
    • Free Webinars
    • Podcast Events
    • Podbean Academy
    • Podcasting Smarter
  • Podbean

    • About Us
    • Careers We are hiring !
    • Affiliate Program
    • Badges
    • Terms of Use
    • Privacy Policy
    • Podbean Blog

Copyright © 2006-2022 Podbean.com