Diabetes and Epigenetics (Jean-Sébastien Annicotte)

Type 2 Diabetes (T2D) is a chronic metabolic disease, which is caused by the failure of beta-cells in the pancreas and insulin resistance in peripheral tissue and characterized by high glucose levels in the blood. World-wide 382 Million people suffer from Diabetes which makes up 8,3% of the population. Due to this high proportion it is of high interest to find a cure for this disease.

The restoration of β-cell mass and function has therefore become a field of intensive research seeking for the next generation of anti-diabetic drugs. Tremendous efforts have been made on deciphering epigenetic regulations that control metabolic tissue function. For several years, the team led by Dr. Jean-Sebastien Annicotte has dissected the molecular links between insulin producing cells, insulin target tissues and T2D/obesity development. Especially, the team research has been focused on the role of cell cycle regulators and their transcriptional co-regulators in the control of metabolic homeostasis, T2D and obesity.

 

References

• Jean-Sébastien Annicotte, Elisabeth Fayard, … Johan Auwerx (2003) Pancreatic-Duodenal Homeobox 1 Regulates Expression of Liver Receptor Homolog 1 during Pancreas Development (Molecular and Cellular Biology) DOI: 10.1128/MCB.23.19.6713-6724.2003 
• Jean-Sébastien Annicotte, Emilie Blanchet, … Lluis Fajas (2009) The CDK4-pRB-E2F1 pathway controls insulin secretion (Nature Cell Biology) DOI: 10.1038/ncb1915 
• Emilie Blanchet, Jean-Sébastien Annicotte, … Lluis Fajas (2011) E2F transcription factor-1 regulates oxidative metabolism (Nature Cell Biology) DOI: 10.1038/ncb2309
• Nabil Rabhi, Pierre-Damien Denechaud, … Jean-Sébastien Annicotte (2016) KAT2B Is Required for Pancreatic Beta Cell Adaptation to Metabolic Stress by Controlling the Unfolded Protein Response (Cell Reports) DOI: 10.1016/j.celrep.2016.03.079
• Albert Giralt, Pierre-Damien Denechaud, … Lluis Fajas (2018) E2F1 promotes hepatic gluconeogenesis and contributes to hyperglycemia during diabetes (Molecular Metabolism) DOI: 10.1016/j.molmet.2018.02.011

 

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