Cancer Immunotherapy: CRISPR Reveals Targets In Vivo

Welcome to The Scientist Speaks, a podcast produced by The Scientist’s Creative Services Team. Our podcast is by scientists and for scientists. Once a month, we bring you the stories behind news-worthy molecular biology research.

This episode is brought to you by 10x Genomics. 10x Genomics builds solutions to interrogate biological systems at a resolution and scale that matches the complexity of biology. Their rapidly expanding suite of products, which include instruments, consumables, and software, has enabled customers to make fundamental discoveries across multiple research areas, including cancer, immunology, and neuroscience.

While T cell immunotherapies effectively battle certain cancers, many cancers do not respond to these treatments. To find solutions to this problem, researchers use modern genetic techniques, such as genome-wide CRISPR-based screens, to enhance the anti-cancer immune response and increase cancer cell susceptibility to treatment. Niki Spahich from The Scientist’s Creative Services team spoke with Sidi Chen, assistant professor in genetics and systems biology at Yale University, to learn more.

To hear a fascinating story about using CRISPR screens, stem cell technology, and single cell sequencing to understand neuron stress and neurodegenerative diseases, check out our latest LabTalk episode at www.the-scientist.com/labtalkepisode2.