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About This Episode:
The Sydney Diet-Heart Study was a clinical trial conducted in the 1960s and 1970s that aimed to examine the hypothesis that reducing saturated fat intake in the diet would lead to a reduced risk of heart disease.
However, it really only gained attention after a more recent re-analysis by Ramsden et al., which in recent years has been used as supporting evidence for the idea that increased polyunsaturated fat (PUFA), and specifically linoleic acid, in addition to reduced saturated fat intake, can increase heart disease risk.
This was based on the findings that substituting linoleic acid in place of saturated fat increased all-cause, CVD and CHD mortality.
This is of course counter to prevailing consensus and guidelines in this area, which routinely show reduced risk on replacing SFA with PUFA.
Could this trial undermine the common conclusions that replacing saturated fat with polyunsaturated fat decreases heart disease risk?
In this episode Alan and Danny discuss some of the crucial aspects to understand about this study and what it means for what conclusions can be made about the impact of PUFA broadly, and linoleic acid specifically, on our health.
#521: How Does Coffee Impact Our Health?
#520: How Exercise Impacts Appetite, Food Intake and Adiposity – James Dorling, PhD
SNP28: How To Eat for Longevity
#519: Eating Disorders: Inpatient Treatment & Challenges – Helen West, RD
#518: Nutritional Geometry, Philosophy of Science & A Case for Reductionism – Prof. David Raubenheimer & Jonathan Sholl, PhD
#517: Reflecting on Ten Years of Lessons
#516: How to Read Nutrition Studies (Become Confident in Critically Appraising Research)
AMA: Do Low-carbers Need Less Vitmain C? Does Omega-3 Supplementation Actually Benefit Us? & More (SNP 27)
#515: Does Dietary Fat Quality Causally Affect Atherosclerosis Risk? – Jacob Christensen, PhD
#514: Plant-derived Fatty Acids – Ella Baker, PhD
#513: Kidney Stones & Diet – Deepa Kariyawasam, RD
What are Dietary Reference Intakes? Origins, Development & Use (SNP 26)
#512: Alzheimer’s Disease – Drs. Ayesha & Dean Sherzai
#511: Null By Design – When “No Effect” Doesn’t Mean No Effect
#510: Social Comparison: Evidence on its Impacts & What We Can Do – Shannon Beer
AMA: Coconut Oil, Raw Oats, Collagen, & More! (SNP 25)
#509: Helping Clients & Patients Overcome Nutrition Confusion – Jono Steedman, APD
#508: Why Athletes Can Achieve High Performance During an Energy Deficit – Jose Areta, PhD
#507: Does a Higher Portfolio Diet Score Reduce Heart Disease? – Andrea Glenn, PhD
Listener Q&A: Homocysteine, MUFA, Healhty BMI, and more! (Preview)
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