In this episode, we hear the argument in favor of the new Alzheimer's drug, Aducanumab (Aduhelm). Dr. Marwan Sabbagh is a clinical and research leader at the Cleveland Clinic's Lou Ruvo Center for Brain Health. He was a doctor that saw patients in one of the trials that led to the FDA's Accelerated (provisional) Approval.
Note: Dr. Sabbagh notes his disclosure as an advisor to Biogen, the maker of Aducanumab.
We discuss what Dr. Sabbagh noted in his own patients involved in the recent Phase 3 clinical trial of Aducanumab.
Controversy over the FDA's decision and why Dr. Sabbagh's 25+ years of diagnosing and treating Alzheimer's makes him optimistic about this drug.
Dr. Sabbagh talks through who he thinks might be a good candidate for Aducanumab, the drug's known practical side effects, and how people might get access to the medication in the near future.
Ultimately, Dr. Sabbagh sees people in the near future living with Alzheimer's like a chronic disease much like HIV or diabetes, or even cancer.
This episode presents a slightly different perspective than many of our listeners are used to. We hope you find it useful.
2:33 - what is this new drug and how does it actually treat Alzheimer's
5:28 - Why Dr. Sabbagh is optimistic about this new drug
11:43 - Reasons for some of the skepticism around the study
14:11 - Dr. Sabbagh’s observations of the people who have taken the drug
21:10 - What are the risks of taking the drug?
27:08 - Responding to the criticism of the drug
32:30 - Other promising drugs that may be available in the future for Alzheimer's patients
37:18 - How do people get access to this new drug?
Alzheimer’s Disease - Going Beyond the Hypothesis
Brain Stimulation for Early Alzheimer's Disease
Strong Heart, Sharp Mind with Marwan Sabbagh MD
Plasma Exchange, Albumin & IVIg for Alzheimer's - AMBAR Trial Results with Merce Boada MD PhD
Towards Understanding "Lyme" & Alzheimer's Relationships with Alan MacDonald MD
Our Sense of Smell - Brainwaves of COVID and Alzheimer's with Thom Cleland PhD
Our Brains Need Meditation - Here's Why with Hemal Patel PhD
Lisa's Story - Chap. 2 - Living Well with Alzheimer's
Usable Technology for Brain Aging & Dementia with Ben Hampstead PhD
Your Brain On Sugar
Working with Trauma in Alzheimer's & Dementia
Why I'm excited about Aducanumab (Aduhelm)!
Living well with Alzheimer's - Lisa's story of getting back to herself.
People Getting Better- More Trial Results with Drs Ann Hathaway & Deborah Gordon
New Study Results with Drs Kat Toups & Dale Bredesen
Being Patient - The Evolution of Data in Alzheimer's & Dementia with Deborah Kan
Pushing Back Against Dementia - Chrissy's Journey
A Patient Story: The Heart-Brain Connection & Energy
Taking Hormones After Menopause - New Data with Felice Gersh MD
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