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About This Episode:
It has been clearly demonstrated that elevated LDL-cholesterol (LDL-C), or perhaps more specifically pro-atherogenic lipoproteins, is causal in atherosclerosis development in humans.
One crucial concept within this is that the risk relates not only to the magnitude of elevated LDL-C, but the duration of exposure. Thus, the role of LDL-C in driving atherosclerosis is referred to as a “cumulative, integrated exposure over the lifecourse”.
But, what exactly does this mean?
In this episode, Danny discusses the cumulative exposure model of LDL-C in atherosclerosis, the evidence supporting it, and the implications of this for the “debates” that get raised in relation to LDL-C (or apoB-containing lipoproteins) and heart disease.
Links:
#521: How Does Coffee Impact Our Health?
#520: How Exercise Impacts Appetite, Food Intake and Adiposity – James Dorling, PhD
SNP28: How To Eat for Longevity
#519: Eating Disorders: Inpatient Treatment & Challenges – Helen West, RD
#518: Nutritional Geometry, Philosophy of Science & A Case for Reductionism – Prof. David Raubenheimer & Jonathan Sholl, PhD
#517: Reflecting on Ten Years of Lessons
#516: How to Read Nutrition Studies (Become Confident in Critically Appraising Research)
AMA: Do Low-carbers Need Less Vitmain C? Does Omega-3 Supplementation Actually Benefit Us? & More (SNP 27)
#515: Does Dietary Fat Quality Causally Affect Atherosclerosis Risk? – Jacob Christensen, PhD
#514: Plant-derived Fatty Acids – Ella Baker, PhD
#513: Kidney Stones & Diet – Deepa Kariyawasam, RD
What are Dietary Reference Intakes? Origins, Development & Use (SNP 26)
#512: Alzheimer’s Disease – Drs. Ayesha & Dean Sherzai
#511: Null By Design – When “No Effect” Doesn’t Mean No Effect
#510: Social Comparison: Evidence on its Impacts & What We Can Do – Shannon Beer
AMA: Coconut Oil, Raw Oats, Collagen, & More! (SNP 25)
#509: Helping Clients & Patients Overcome Nutrition Confusion – Jono Steedman, APD
#508: Why Athletes Can Achieve High Performance During an Energy Deficit – Jose Areta, PhD
#507: Does a Higher Portfolio Diet Score Reduce Heart Disease? – Andrea Glenn, PhD
Listener Q&A: Homocysteine, MUFA, Healhty BMI, and more! (Preview)
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