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About This Episode:
PREDIMED (Prevención con Dieta Mediterránea) is a landmark clinical trial conducted in Spain.
The study made a huge splash due to the rarity in nutrition of having large RCTs with hard endpoints. In addition, it had results of a large magnitude; showing a 30% reduction in cardiovascular events.
But the study did face criticisms and controversies over methodological issues, including randomization procedures at certain centers, ultimately leading to a retraction of the original paper and a re-analysis.
Participants in the PREDIMED trial were randomly assigned to one of three groups:
Despite the issues it still ends up being an incredibly useful source of data.
In this episode we discuss the findings from PREDIMED, some of the potential limitations, and where it sits among the wider Mediterranean Diet literature.
Note: This is a Premium-exclusive episode, so in order to listen to the full episode you’ll need to subscribe to Sigma Nutrition Premium.
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#520: How Exercise Impacts Appetite, Food Intake and Adiposity – James Dorling, PhD
SNP28: How To Eat for Longevity
#519: Eating Disorders: Inpatient Treatment & Challenges – Helen West, RD
#518: Nutritional Geometry, Philosophy of Science & A Case for Reductionism – Prof. David Raubenheimer & Jonathan Sholl, PhD
#517: Reflecting on Ten Years of Lessons
#516: How to Read Nutrition Studies (Become Confident in Critically Appraising Research)
AMA: Do Low-carbers Need Less Vitmain C? Does Omega-3 Supplementation Actually Benefit Us? & More (SNP 27)
#515: Does Dietary Fat Quality Causally Affect Atherosclerosis Risk? – Jacob Christensen, PhD
#514: Plant-derived Fatty Acids – Ella Baker, PhD
#513: Kidney Stones & Diet – Deepa Kariyawasam, RD
What are Dietary Reference Intakes? Origins, Development & Use (SNP 26)
#512: Alzheimer’s Disease – Drs. Ayesha & Dean Sherzai
#511: Null By Design – When “No Effect” Doesn’t Mean No Effect
#510: Social Comparison: Evidence on its Impacts & What We Can Do – Shannon Beer
AMA: Coconut Oil, Raw Oats, Collagen, & More! (SNP 25)
#509: Helping Clients & Patients Overcome Nutrition Confusion – Jono Steedman, APD
#508: Why Athletes Can Achieve High Performance During an Energy Deficit – Jose Areta, PhD
#507: Does a Higher Portfolio Diet Score Reduce Heart Disease? – Andrea Glenn, PhD
Listener Q&A: Homocysteine, MUFA, Healhty BMI, and more! (Preview)
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