480 | Dr. Jeff Graham | Neurodegenerative Disease & Metabolic Dysfunction: Healthspan Series, Part 3

Description:
In the third and final episode of the healthspan series, Dr. Erin Faules and Dr. Jeff Graham explore the intersection between neurodegenerative disease and metabolic dysfunction—two often-connected drivers of decline. They discuss early detection strategies, the role of genetics, and insulin resistance, and emerging clinical tools to assess and reduce long-term risk.
Key Topics Covered:

• Distinguishing normal aging from neurodegenerative disease
• Early signs of cognitive decline and how to detect them
• The role of APOE-4 and other genes in Alzheimer's risk
• Metabolic dysfunction as a driver of brain aging ("Type 3 diabetes")
• Blood-based biomarkers: phospho-tau, NFL, CRP, fasting insulin, and more
• Lifestyle interventions: sleep, strength training, CGMs, circadian-aligned eating
• Tools like CNS Vital Signs, PET scans, and neuroquant MRIs
• Supplements and prescriptions: Omega-3s, creatine, berberine, GLP-1s, inositol
• Connecting muscle mass to glucose control and long-term healthspan