In this episode:
00:46 A virtual chemical library uncovers potential antidepressants
Certain psychedelic drugs are of interest to researchers due to their promising antidepressant effects. To help speed up the discovery of molecules with useful properties, researchers have built a virtual library of 75 million compounds related to these drugs. This approach yielded two molecules that showed antidepressant properties in mice, but without the hallucinogenic activity of psychedelic drugs.
Research article: Kaplan et al.
Research Briefing: Bespoke library docking for 5-HT2A receptor agonists with antidepressant activity
08:25 Research Highlights
Research suggests that ancient artificial island settlements were hubs of activity for society’s elite, and astronomers spot possibly the most luminous star ever observed.
Research Highlight: Ancient DNA suggests that artificial islands were party spots for the elite
Research Highlight: Scientists face down ‘Godzilla’, the most luminous star known
10:42 Nobel News
Flora Graham from the Nature Briefing joins us to talk about the winners of this year’s Nobel Prizes.
Nature News: Geneticist who unmasked lives of ancient humans wins medicine Nobel
Nature News: ‘Spooky’ quantum-entanglement experiments win physics Nobel
Nature News: Chemists who invented revolutionary 'click' reactions win Nobel
Enter Nature’s ‘Scientist at Work’ photo competition, full details here
Subscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday.
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Audio long-read: How ancient people fell in love with bread, beer and other carbs
Coronapod: the latest on COVID and sporting events
How the US is rebooting gun violence research
Coronapod: Does England's COVID strategy risk breeding deadly variants?
How deadly heat waves expose historic racism
Coronapod: Will COVID become a disease of the young?
Food shocks and how to avoid them
Coronapod: the biomarker that could change COVID vaccines
The scientist whose hybrid rice helped feed billions
Audio long-read: How COVID exposed flaws in evidence-based medicine
Coronapod: should you have a COVID vaccine when breastfeeding?
Quantum compass might help birds 'see' magnetic fields
CureVac disappoints in COVID vaccine trial
Communities, COVID and credit: the state of science collaborations
Coronapod: Counting the cost of long COVID
Google AI beats humans at designing computer chips
Coronapod: Uncertainty and the COVID 'lab-leak' theory
On the origin of numbers
New hope for vaccine against a devastating livestock disease
Audio long-read: How harmful are microplastics?
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