In this episode:
00:46 A virtual chemical library uncovers potential antidepressants
Certain psychedelic drugs are of interest to researchers due to their promising antidepressant effects. To help speed up the discovery of molecules with useful properties, researchers have built a virtual library of 75 million compounds related to these drugs. This approach yielded two molecules that showed antidepressant properties in mice, but without the hallucinogenic activity of psychedelic drugs.
Research article: Kaplan et al.
Research Briefing: Bespoke library docking for 5-HT2A receptor agonists with antidepressant activity
08:25 Research Highlights
Research suggests that ancient artificial island settlements were hubs of activity for society’s elite, and astronomers spot possibly the most luminous star ever observed.
Research Highlight: Ancient DNA suggests that artificial islands were party spots for the elite
Research Highlight: Scientists face down ‘Godzilla’, the most luminous star known
10:42 Nobel News
Flora Graham from the Nature Briefing joins us to talk about the winners of this year’s Nobel Prizes.
Nature News: Geneticist who unmasked lives of ancient humans wins medicine Nobel
Nature News: ‘Spooky’ quantum-entanglement experiments win physics Nobel
Nature News: Chemists who invented revolutionary 'click' reactions win Nobel
Enter Nature’s ‘Scientist at Work’ photo competition, full details here
Subscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday.
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How virtual meetings can limit creative ideas
Audio long-read: The quest to prevent MS — and understand other post-viral diseases
We could still limit global warming to just 2˚C — but there's an 'if'
Coronapod: Infected immune cells hint at cause of severe COVID
Why do naked mole rats live as long as giraffes?
Five years in the coldest fridge in the known Universe
Audio long-read: A more-inclusive genome project aims to capture all of human diversity
Winding roads could make you a better navigator
Milky Way's origin story revealed by 250,000 stars
Coronapod: How vaccine complacency is plaguing 'COVID zero' strategies
The coin toss of Alzheimer's inheritance
The vest that can hear your heartbeat
The AI that deciphers ancient Greek graffiti
Coronapod: why stopping COVID testing would be a mistake
COVID stimulus spending failed to deliver on climate promises
Audio long-read: The race to save the Internet from quantum hackers
Dinosaur-destroying asteroid struck in spring
Tongan volcano eruption leaves scientists with unanswered questions
Coronapod: How African scientists are copying Moderna's COVID vaccine
RNA test detects deadly pregnancy disorder early
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