FULL EPISODE HERE: https://youtu.be/x_hEHVpFy5k?si=tTZzlQg3F2IsBYdW
I’m diving into vitamin C with Dan Pardi, who brings a research-focused perspective to what may be one of the most underestimated nutrients in healthy aging. We explore how absorption changes as you get older, why form and timing matter, and what vitamin C may have to do with exercise adaptation, cellular senescence, brain health, and biological aging. I also get into the practical questions you’re probably asking, including how much to take, when to take it, and how vitamin C might fit into a bigger longevity strategy.
(00:00) How the sodium-dependent vitamin C transporter acts like a turnstile to limit standard ascorbic acid absorption.
(01:14) Why combining liposomal and buffered forms with bioflavonoids maximizes plasma vitamin C retention.
(01:56) How aging drastically decreases nutrient absorption while simultaneously increasing cellular demand and utilization.
(05:03) Why taking high doses of antioxidants too close to resistance training blunts key exercise adaptations.
(06:10) How adrenal and brain accumulation of vitamin C can cause nighttime alertness if taken too late in the day.
(08:48) The essential difference between measuring your accumulated biological age and your current pace of aging.
(10:42) How targeted vitamin C therapy slows cellular senescence and reduces systemic neuroinflammation.
(13:25) The crucial role of vitamin C as a cofactor for two key enzymes that synthesize strong, flexible collagen.
Full show notes (including all links mentioned): https://jjvirgin.com/danpardi