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About This Episode:
Alzheimer’s disease has a profound impact on individuals, families, and societies worldwide. As a progressive neurodegenerative disease, it not only robs individuals of their cognitive abilities but also places an immense emotional and economic burden on caregivers.
Mechanistically, the causes of Alzheimer’s are incredibly complex and not fully understood. And in terms of treatment, the landscape appears challenging. Drug discovery efforts for dementias, including Alzheimer’s, have faced setbacks, leaving a void in effective treatments. Consequently, attention has shifted toward preventive strategies, including dietary patterns.
From a prevention standpoint, both genetics and lifestyle should be considered. Which throws up many interesting questions…
To what extent do genetic factors contribute to Alzheimer’s risk compared to lifestyle choices, and how does this interaction influence disease development?
What role does lifestyle play in Alzheimer’s risk, and is there evidence supporting the influence of specific nutrients on cognitive health?
How do diet patterns impact Alzheimer’s risk? Are there discernible risk differences associated with specific dietary choices, and how do these interact with genetic factors, such as the ApoE genotype?
In this episode, Drs. Ayesha Sherzai and Dean Sherzai are on the podcast to answer these questions and discuss this topic in more depth.
About The Guests:
Dr. Ayesha Sherzai is a neurologist and co-director of the Alzheimer’s Prevention Program at Loma Linda University, where she leads the Lifestyle Program for the Prevention of Neurological Diseases. She completed a dual training in Preventative Medicine and Neurology at Loma Linda University, and a fellowship in Vascular Neurology and Epidemiology at Columbia University. She is also a trained plant-based culinary artist.
Dr. Dean Sherzai is co-director of the Alzheimer’s Prevention Program at Loma Linda University. Dean trained in Neurology at Georgetown University School of Medicine, and completed fellowships in neurodegenerative diseases and dementia at the National Institutes of Health and UC San Diego. He also holds a PhD in Healthcare Leadership with a focus on community health from Andrews University.
#370: Jake Mey, PhD, RD - Dietetics, Evidence-based Practice & Translating Science into Advice
#369: Prof. Jason Gill - Population Cardiometabolic Disease Risk: Impact of Strength, Fitness & Activity
#368: Shannon Beer – Intentional Eating, Flourishing Health & Behavioural Psychology
#367: Gabrielle Fundaro, PhD – Mindful Eating, Facilitating Health Behaviour Change & Client-centred Coaching
#366: Listener Q&A
#365: David Robert Grimes, PhD – Conspiracy Theories & Bad Information: Why Are We Susceptible?
#364: Jake Linardon, PhD - Disordered Eating: Impact of Macro Tracking & Social Media
#363: Public Health Policy vs. Personal Responsibility: Evidence vs. Ideology
#362: Alistair Monteyne – Impact of Mycoprotein & Vegan Diets on Muscle Protein Synthesis
#361: Sarah Berry, PhD – The PREDICT Study, Postprandial Metabolism & Personalised Nutrition
#360: Nick Hiebert – Micronutrients, Anti-nutrients and Non-essential Nutrients
#359: Calorie Confusion - (Mis)Understanding Energy Balance
#358: Coffee & Health
#357: Nicky Keay, MB BChir – Female Athletes: Hormones, Energy Availability & the Menstrual Cycle
#356: Hana Kahleova, MD, PhD – Plant-based Diets, Meal Timing & Meal Frequency
#355: Is Time-restricted Eating Dead?: A Closer Look
#354: Problems with the Meta-Analysis in Nutrition
#353: James Hébert, ScD – Dietary Inflammatory Index
#352: Do Diets Even Work in the Long-term? - A Look at Weight Loss Maintenance
#351: Prof. Glenn Gibson - Human Gut Bacteriology, Prebiotics & Probiotics
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