If you are interested in lipids, you’ve probably heard of Dave Feldman and his work. If not, you’ve got some homework to do, and I think you’ll be amazed at what you find. Dave’s work can be found at cholesterolcode.com where he details his multiple, meticulous self-experimental projects. Prior to cholesterol adventures Dave was a senior software scientist and an engineer. He brings this “out of the box” thinking to the world of medicine and we are all better off for it.
He began a low-carb, high-fat diet in April 2015 and has since learned everything he could about it with special emphasis on cholesterol. He saw his own lipid numbers spike substantially after going on the diet and spotted a pattern in the lipid system that’s very similar to distributed objects in networks.
Time Stamps:
0:09:20 Podcast begins with Dave Feldman
0:09:45 Responding to the common question: "I feel so good on Animal-Based, but my cholesterol is sky high. What's going on?"
0:20:05 The importance of context in regards to cholesterol
0:26:20 Just because cholesterol is involved in asc sclerosis, that does not mean it is the cause of asc sclerosis
0:33:50 Inflammation and it's role with asc sclerosis
0:36:00 Do we have any experiments that shows LDL is directly harmful to humans?
0:47:05 The more saturated fat you eat, the higher your LDL goes, but does this result in more chronic disease?
0:57:35 PUFA's are essential for humans, but if you're eating saturated fat from grass-fed ruminant animals, you will not become deficient
1:02:44 Familial hypercholesterolemia (FH) and healthy individuals
1:07:40 Macrophages of genetically characterized familial hypercholesterolaemia patients show up‐regulation of LDL‐receptor‐related proteins: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323824/
1:14:20 A 72-Year-Old Patient with Longstanding, Untreated Familial Hypercholesterolemia but no Coronary Artery Calcification: A Case Report: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991918/
1:15:20 Chimpanzee VS Human LDL
1:15:45 Chimpanzee serum lipoproteins. Isolation, characterisation and comparative aspects of the low density lipoprotein and apolipoprotein-BH: https://pubmed.ncbi.nlm.nih.gov/6477668/
1:25:05 Distribution of glycosaminoglycans in the intima of human aortas: changes in atherosclerosis and diabetes mellitus: https://pubmed.ncbi.nlm.nih.gov/8477876/
1:29:20 The importance of hemostasis and how it relates to blood clots
1:35:40 Xanthoma in lean-mass hyper responders who do not have FH
1:40:50 Low Triglycerides–High High-Density Lipoprotein Cholesterol and Risk of Ischemic Heart Disease: https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/647239
1:44:00 Hyperlipidaemia does not impair vascular endothelial function in glycogen storage disease type 1a: https://linkinghub.elsevier.com/retrieve/pii/0021915094900728
1:47:35 If a patient has a rising LDL, but is otherwise healthy, what does Dave suggest?
1:53:00 https://citizensciencefoundation.org/ and where to find more of Dave's work
1:54:30 Dave's current diet
Sponsors:
Heart & Soil: www.heartandsoil.co
White Oak Pastures: www.Whiteoakpastures.com, use
209. Why PEANUT BUTTER is one of the worst foods with Dave Asprey
208. NFL player eats ANIMAL-BASED with Taylor Rapp from the LA Rams
207. Oxalates are ruining your health with Sally Norton
206. James DiNicolantonio: supplementation and nutrient deficiencies, eggs vs. bagels for weight loss, creatine and diet
205. Secret diets across the world with Forrest Galante
204. Top health habits to thrive in 2023: Paul Saladino on Radical Health Radio
203. Eat meat, save the planet. With Will Harris
202. Debunking common vegan arguments
201. Most frequently asked questions: cholesterol, vegetables, diabetes, organs, heart disease, and more!
200. Is animal-based the optimal human diet? A conversation with Georgi Dinkov
199. Is all sugar bad for you? High fructose corn syrup vs fruit & honey
198. Misinformation: the dangers of banning my post on seed oils
197. Are artificial sweeteners making you fat?
196. Animal-based diet 101: 2023 edition
195. The best of the Fundamental Health podcast, 2022 year in review
194. Animal-based vs. Ray Peat diet, a conversation with Georgi Dinkov
193. Bloodwork review: December 2022
192. What I eat in a day: Detailed nutritional analysis
191. Everything we’ve been lied to about: Weight loss, cholesterol, and seed oils, Kyle Kingsbury interviews Paul
190. What a cardiologist thinks of my cholesterol, with Michael Twyman, MD
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