If you are interested in lipids, you’ve probably heard of Dave Feldman and his work. If not, you’ve got some homework to do, and I think you’ll be amazed at what you find. Dave’s work can be found at cholesterolcode.com where he details his multiple, meticulous self-experimental projects. Prior to cholesterol adventures Dave was a senior software scientist and an engineer. He brings this “out of the box” thinking to the world of medicine and we are all better off for it.
He began a low-carb, high-fat diet in April 2015 and has since learned everything he could about it with special emphasis on cholesterol. He saw his own lipid numbers spike substantially after going on the diet and spotted a pattern in the lipid system that’s very similar to distributed objects in networks.
Time Stamps:
0:09:20 Podcast begins with Dave Feldman
0:09:45 Responding to the common question: "I feel so good on Animal-Based, but my cholesterol is sky high. What's going on?"
0:20:05 The importance of context in regards to cholesterol
0:26:20 Just because cholesterol is involved in asc sclerosis, that does not mean it is the cause of asc sclerosis
0:33:50 Inflammation and it's role with asc sclerosis
0:36:00 Do we have any experiments that shows LDL is directly harmful to humans?
0:47:05 The more saturated fat you eat, the higher your LDL goes, but does this result in more chronic disease?
0:57:35 PUFA's are essential for humans, but if you're eating saturated fat from grass-fed ruminant animals, you will not become deficient
1:02:44 Familial hypercholesterolemia (FH) and healthy individuals
1:07:40 Macrophages of genetically characterized familial hypercholesterolaemia patients show up‐regulation of LDL‐receptor‐related proteins: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323824/
1:14:20 A 72-Year-Old Patient with Longstanding, Untreated Familial Hypercholesterolemia but no Coronary Artery Calcification: A Case Report: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991918/
1:15:20 Chimpanzee VS Human LDL
1:15:45 Chimpanzee serum lipoproteins. Isolation, characterisation and comparative aspects of the low density lipoprotein and apolipoprotein-BH: https://pubmed.ncbi.nlm.nih.gov/6477668/
1:25:05 Distribution of glycosaminoglycans in the intima of human aortas: changes in atherosclerosis and diabetes mellitus: https://pubmed.ncbi.nlm.nih.gov/8477876/
1:29:20 The importance of hemostasis and how it relates to blood clots
1:35:40 Xanthoma in lean-mass hyper responders who do not have FH
1:40:50 Low Triglycerides–High High-Density Lipoprotein Cholesterol and Risk of Ischemic Heart Disease: https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/647239
1:44:00 Hyperlipidaemia does not impair vascular endothelial function in glycogen storage disease type 1a: https://linkinghub.elsevier.com/retrieve/pii/0021915094900728
1:47:35 If a patient has a rising LDL, but is otherwise healthy, what does Dave suggest?
1:53:00 https://citizensciencefoundation.org/ and where to find more of Dave's work
1:54:30 Dave's current diet
Sponsors:
Heart & Soil: www.heartandsoil.co
White Oak Pastures: www.Whiteoakpastures.com, use
169. Do cows cause climate change?
168. Why I don't worry about my cholesterol
167. Why I don't eat fish, chicken or pork!
166. AMA (Ask me anything): Black seed oil, polyester clothes, carbohydrate cravings, constipation, and how to detox from seed oils...
165. Are plant-based diets appropriate for children and pregnancy? With Ex-Vegan Jon Venus
164. Dietary guidelines recommend meat/organs as the ideal first food for infants!
163. Live AMA (Ask Me Anything) at the 2022 Animal Based Gathering
162. Naked tanning, benefits, skin cancer risk, dangers of sunscreen
161. Using an Animal Based diet to optimize fertility and pregnancy with Lindsey Meehleis
160. The water episode. Fluoride? Alkaline? Structured? Best type of filtration? And are there contaminants in your spring water?
159. Everything you need to know about starting an Animal Based diet
158. Why now is the worst time to be a Vegan/Vegetarian/Pescatarian ever with Evan Brand
157. The More Plates More Dates podcast with Derek!
156. How to correct the root cause of your depression/anxiety/eating disorder
155. How to fix your low testosterone (and hormones in general!)
154. The Liver King Podcast! With Brian Johnson, aka Liver King
153. Is fruit bad or good for humans? Will organs raise Uric Acid?
152. More myth debunking: TMAO, Neu5gc, Methionine/Glycine balance
151. How plant defense chemicals may trigger autoimmunity. Is Nicotinamide Riboside BS? Is spirulina BS?
150. Nick Bare interviews Paul on The Dangers of Seed oils
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