Sam Apple is the author of the book Ravenous: Otto Warburg, the Nazis, and the Search for the Cancer-Diet Connection, published in May 2021. In this episode, Sam describes the fascinating life story of Otto Warburg, a Nobel Prize-winning scientist who, despite being both Jewish and gay, survived Nazi Germany because of his valuable research on cellular metabolism and cancer. Sam describes Warburg’s observation that cancer cells consume large amounts of glucose anaerobically – a phenomenon subsequently known as the “Warburg Effect” – and relates how Warburg’s seminal work on this topic was largely forgotten after the discovery of oncogenes, only to regain relevance decades later within the field of cancer biology. Sam sheds light on the current debate around Warburg’s interpretation of the causes of cancer, and Peter gives his personal take on the matter. Finally, Peter and Sam tie it all together with a discussion about cancer prevention, the role of hyperinsulinemia, and the link between dietary sugar and cancer.
We discuss:
#137 - Paul Offit, M.D.: An expert perspective on COVID-19 vaccines
#136 - AMA #17: Body composition methods tour de force, insulin resistance, and Topo Chico
#135 - BJ Miller, M.D.: How understanding death leads to a better life
#134 - James O’Keefe, M.D.: Preventing cardiovascular disease and the risk of too much exercise.
#133 - Vinay Prasad, M.D., M.P.H: Hallmarks of successful cancer policy
#132 - AMA #16: Exploring hot and cold therapy
#131 - Beth Lewis: The Art of Stability: Learning about pain, mitigating injury, and moving better through life
#130 - Carol Tavris, Ph.D. & Elliot Aronson, Ph.D.: Recognizing and overcoming cognitive dissonance
#129 - Tom Dayspring, M.D.: The latest insights into cardiovascular disease and lipidology
#128 – Irene Davis, Ph.D.: The evolution of the foot, running injuries, and minimalist shoes
#127 - AMA #3 with sleep expert, Matthew Walker, Ph.D.: Fasting, gut health, blue light, caffeine, REM sleep, and more
#126 – Matthew Walker, Ph.D.: Sleep and immune function, chronotypes, hygiene tips, and addressing questions about his book
#125 - John Arnold: The most prolific philanthropist you may not have heard of
#124 - AMA #15: Real-world case studies—metabolic dysregulation, low testosterone, menopause, and more
#123 - Joan Mannick, M.D. & Nir Barzilai, M.D.: Rapamycin and metformin—longevity, immune enhancement, and COVID-19
#122 - Lori Gottlieb: Understanding pain, therapeutic breakthroughs, and keys to enduring emotional health
#121 - Azra Raza, M.D.: Why we're losing the war on cancer
#120 - AMA with Dom D’Agostino, Ph.D., Part II of II: Ketosis for cancer and chronic disease, hyperbaric oxygen therapy, and the effect of ketosis on female health
#119 - Terry Real: Breaking the cycle of shame, anger, and depression
#118 - Lloyd Klickstein, M.D., Ph.D.: Rapamycin, mTOR inhibition, and the biology of aging
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