Sam Apple is the author of the book Ravenous: Otto Warburg, the Nazis, and the Search for the Cancer-Diet Connection, published in May 2021. In this episode, Sam describes the fascinating life story of Otto Warburg, a Nobel Prize-winning scientist who, despite being both Jewish and gay, survived Nazi Germany because of his valuable research on cellular metabolism and cancer. Sam describes Warburg’s observation that cancer cells consume large amounts of glucose anaerobically – a phenomenon subsequently known as the “Warburg Effect” – and relates how Warburg’s seminal work on this topic was largely forgotten after the discovery of oncogenes, only to regain relevance decades later within the field of cancer biology. Sam sheds light on the current debate around Warburg’s interpretation of the causes of cancer, and Peter gives his personal take on the matter. Finally, Peter and Sam tie it all together with a discussion about cancer prevention, the role of hyperinsulinemia, and the link between dietary sugar and cancer.
We discuss:
Earning the gift of life | Ric Elias (#79 rebroadcast)
#212 - The neuroscience of obesity | Stephan Guyenet, Ph.D.
#211 - AMA #36: Fruits & vegetables—everything you need to know
#210 - Lp(a) and its impact on heart disease | Benoît Arsenault, Ph.D.
#209 ‒ Medical mistakes, patient safety, and the RaDonda Vaught case | Marty Makary, M.D., M.P.H.
The Art of Stability | Beth Lewis (Ep. #131 Rebroadcast)
#208 - Tragedy, grief, healing, and finding happiness | Kelsey Chittick
#207 - AMA #35: "Anti-Aging" Drugs — NAD+, metformin, & rapamycin
#206 - Exercising for longevity: strength, stability, zone 2, zone 5, and more
#205 - Energy balance, nutrition, & building muscle | Layne Norton, Ph.D. (Pt.2)
#204 - Centenarians, metformin, and longevity | Nir Barzilai, M.D.
#203 - AMA #34: What Causes Heart Disease?
#202 - Peter on nutrition, disease prevention, sleep, and more — looking back on the last 100 episodes
In remembrance of Sarah Hallberg, D.O., M.S. (Ep. #162 Rebroadcast)
#201 - Deep dive back into Zone 2 | Iñigo San-Millán, Ph.D. (Pt. 2)
#200 - AMA #33: Hydration—electrolytes, supplements, sports drinks, performance effects, and more
#199 - Running, overcoming challenges, and finding success | Ryan Hall
#198 - Eye health—everything you need to know | Steven Dell, M.D.
#197 - The science of obesity & how to improve nutritional epidemiology | David Allison, Ph.D.
#196 - AMA #32: Exercise, squats, deadlifts, BFR, and TRT
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