This Week in Pediatric Oncology
Science
May 19, 2011
Discussion of the role of hedgehog signaling and repositioning of drugs for pediatric cancers such as anti-fungal drug itraconazole
In this fifth episode, hosts Dr. Tim Cripe and Dr. Maureen O'Brien discuss the role of targeting of hedgehog signaling in diffuse intrinsic pontine glioma (DIPG) and the use of drugs designed for other uses -- designed for other uses -- such as itraconazole, an anti-fungal drug found to suppress hedgehog signaling -- as a possible treatment for medulloblastoma.
1:20 feedback and comments on previous TWiPO episode
2:58 Hedgehog-responsive candidate cell of origin for diffuse intrinsic pontine glioma; (fulltext) Proc Natl Acad Sci U S A. 2011 March 15; 108(11): 4453–4458
9:22 Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth. Cancer Cell. 2010 Apr 13;17(4):388-99.
TWiPO #72 - Dr. Eugene Hwang discusses his work with immunotherapy and pseudo-progression
TWiPO #71 - Interview with Nancy Goodman, Founder and Executive Director of Kids v. Cancer
TWiPO #70 - Dr. Joshua Rubin talks about his research done on gender differences to cancer
TWiPO #69 - Dr. Peter Shields talks about the effects of e-cigarettes
TWiPO #68 - Dr. Dean Lee discusses his experience with T-cell CARs
TWiPO #67 - Interview with Dr. Mitchell Cairo
TWIPO #66 - Interview with Dr. Rani George
TWiPO #65 - Interview with Dr. Brenda Weigel
TWiPO #64 - Interview with Dr. Lars Wagner
TWiPO #63 - Dr. Javier Blanco discusses chemotherapy late effects and cardio-toxicity
TWiPO #62 - Interview with Dr. Uri Tabori
TWIPO #61 - Interview with Dr. Matthew Breen
TWIPO #60 - Interview with Dr. Josua Mendell
TWiPo #59 ~ Interview with Dr. Sajid Qureshi
TWiPO #58 ~ Interview with Dr. Damon Reed
TWIPO # 57 Interview with Dr. Elizabeth Lawlor
TWIPO #56 ~ Interview with Dr. Mark Hatley
TWiPO #55 ~ Interview with Dr. Chrystal Louis
TWiPO #54 ~ Interview with Dr. Kim Kramer
TWiPO #53 ~ Interview with Linda McAllister-Lucas
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