This Week in Pediatric Oncology
Science
May 19, 2011
Discussion of the role of hedgehog signaling and repositioning of drugs for pediatric cancers such as anti-fungal drug itraconazole
In this fifth episode, hosts Dr. Tim Cripe and Dr. Maureen O'Brien discuss the role of targeting of hedgehog signaling in diffuse intrinsic pontine glioma (DIPG) and the use of drugs designed for other uses -- designed for other uses -- such as itraconazole, an anti-fungal drug found to suppress hedgehog signaling -- as a possible treatment for medulloblastoma.
1:20 feedback and comments on previous TWiPO episode
2:58 Hedgehog-responsive candidate cell of origin for diffuse intrinsic pontine glioma; (fulltext) Proc Natl Acad Sci U S A. 2011 March 15; 108(11): 4453–4458
9:22 Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth. Cancer Cell. 2010 Apr 13;17(4):388-99.
TWIPO #32 ~ Ethics in Childhood Cancer Clinical Trials
TWIPO #31 ~ Secondary Cancers in Childhood Cancer Survivors
TWIPO #30 ~ Cancer Risk in Families
TWIPO #29 ~ Understanding the Circuitry Behind Pediatric Solid Tumors
TWIPO #28 ~ Uniting the Childhood Cancer Community
TWIPO #27 ~ Advocating for Better Research for our Kids
TWiPO #26 ~ Killer Immunoglobulin Receptor (KIR) Mismatch in Neuroblastoma
TWiPO #25 ~ Histones in Pediatric Gliomas
TWiPO #24 ~ Cord Blood Banking: Interview with Machi Scaradavou
TWiPO #23 ~ Neuroblastoma Jeopardy 2011
TWiPO #22 ~ Brain Tumor Year-End Round Robin
TWiPO #21 ~ Interview with Dr. Beatrice Lampkin
TWiPO #20 ~ The F-word in Pediatric Cancer Research
TWiPO #19 ~ More on Hedgehog signaling, brain tumor risk from cell phone use, and FDA approval of cancer drugs
TWiPO #18 ~ Targeting EWS-FLI1 in Ewing's Sarcoma: Interview with Dr Jeff Toretsky
TWiPO #17 ~ Personalized medicine: Interview with Dr Giselle Sholler
TWiPO #16 ~ Genetic Underpinnings of Ewing Sarcoma: Interview with Dr Stephen L. Lessnick
TWiPO #15 ~ MicroRNAs and hereditary cancer
TWiPO #14 ~ Interview with Dr Kate Matthay
TWiPO #13 ~ Updates, epidemiology of CNS tumors, birth order, and cell phone risks
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