Type 2 Diabetes (T2D) is a chronic metabolic disease, which is caused by the failure of beta-cells in the pancreas and insulin resistance in peripheral tissue and characterized by high glucose levels in the blood. World-wide 382 Million people suffer from Diabetes which makes up 8,3% of the population. Due to this high proportion it is of high interest to find a cure for this disease.
The restoration of β-cell mass and function has therefore become a field of intensive research seeking for the next generation of anti-diabetic drugs. Tremendous efforts have been made on deciphering epigenetic regulations that control metabolic tissue function. For several years, the team led by Dr. Jean-Sebastien Annicotte has dissected the molecular links between insulin producing cells, insulin target tissues and T2D/obesity development. Especially, the team research has been focused on the role of cell cycle regulators and their transcriptional co-regulators in the control of metabolic homeostasis, T2D and obesity.
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When is a Peak a Peak? (Claudio Cantù)
Analysis of 3D Chromatin Structure Using Super-Resolution Imaging (Alistair Boettiger)
Gene Dosage Alterations in Evolution and Ageing (Claudia Keller Valsecchi)
Structural Analysis of Nucleosomes During Transcription (Lucas Farnung)
DNA Methylation Alterations in Neurodegenerative Diseases (Paula Desplats)
scDamID, EpiDamID and Lamina Associated Domains (Jop Kind)
Circulating Epigenetic Biomarkers in Cancer (Charlotte Proudhon)
Epigenetic Landscapes During Cancer (Luciano Di Croce)
Formation of CenH3-deficient Kinetochores (Ines Drinnenberg)
Effects of Environmental Cues on the Epigenome and Longevity (Paul Shiels)
The Epigenetics of Human Sperm Cells (Sarah Kimmins)
Transgenerational Inheritance and Evolution of Epimutations (Peter Sarkies)
Transcription Elongation Control by the Paf1 Complex (Karen Arndt)
Molecular Mechanisms of Chromatin Modifying Enzymes (Karim-Jean Armache)
The Role of PHF13 in Chromatin and Transcription (Sarah Kinkley)
Genome Organization Mediated by RNA Polymerase II (Argyrys Papantonis)
The Role of Pioneer Factors Zelda and Grainyhead at the Maternal-to-Zygotic Transition (Melissa Harrison)
Epigenetics in Human Malaria Parasites (Elena Gómez-Diaz)
Bioinformatic Analysis in Epigenetics Research (Nick Pervolarakis)
Anchor-Based Bisulfite Sequencing (Ben Delatte)
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