Type 2 Diabetes (T2D) is a chronic metabolic disease, which is caused by the failure of beta-cells in the pancreas and insulin resistance in peripheral tissue and characterized by high glucose levels in the blood. World-wide 382 Million people suffer from Diabetes which makes up 8,3% of the population. Due to this high proportion it is of high interest to find a cure for this disease.
The restoration of β-cell mass and function has therefore become a field of intensive research seeking for the next generation of anti-diabetic drugs. Tremendous efforts have been made on deciphering epigenetic regulations that control metabolic tissue function. For several years, the team led by Dr. Jean-Sebastien Annicotte has dissected the molecular links between insulin producing cells, insulin target tissues and T2D/obesity development. Especially, the team research has been focused on the role of cell cycle regulators and their transcriptional co-regulators in the control of metabolic homeostasis, T2D and obesity.
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Effects of DNA Methylation on Chromatin Structure and Transcription (Dirk Schübeler)
CpG Islands, DNA Methylation, and Disease (Adrian Bird)
Biophysical Modeling of 3-D Genome Organization (Leonid Mirny)
From Nucleosome Structure to Function (Karolin Luger)
Identification of Functional Elements in the Genome (Bing Ren)
Hi-C and Three-Dimensional Genome Sequencing (Erez Lieberman Aiden)
Chromatin Structure and Dynamics at Ribosomal RNA Genes (Tom Moss)
Epigenetic Origins Of Heterogeneity And Disease (Andrew Pospisilik)
PIXUL: On the Leading Edge of Chromatin Shearing (Karol Bomsztyk and Tom Matula)
Influence of Histone Variants on Chromatin Structure and Metabolism (Markus Buschbeck)
Epigenetic Mechanisms of Aging and Longevity (Shelley Berger)
Epigenetics & Glioblastoma: New Approaches to Treat Brain Cancer (Lucy Stead)
The Past, Present, and Future of Epigenetics (Joe Fernandez, founder of Active Motif)
The Interchromatin Network Model (Ana Pombo)
Dosage Compensation in Drosophila (Asifa Akhtar)
Spatial Organization of the Human Genome (Wendy Bickmore)
Heterochromatin and Phase Separation (Gary Karpen)
Epigenetics and X-inactivation (Edith Heard)
Chromatin Organization (Susan Gasser)
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