Is there one microRNA playing a primary role in the complex pathogenesis of right ventricular failure caused by pulmonary hypertension? Listen as Associate Editor Fabio Recchia (Temple University Lewis Katz School of Medicine, and Scuola Superiore Sant'Anna, Pisa, Italy) interviews lead author Sachin Gupte (New York Medical College) and content expert Paras Mishra (University of Nebraska Medical Center) about the work by Joshi et al, which used microarray analysis to focus on MiR140 as a potential therapeutic target in a Sugen5416/hypoxia/normoxia model of pulmonary arterial hypertension (PAH). Is MiR31 also a major player in the pathogenesis of this disease? What is the translational relevance of the work by Gupte and colleagues on afterload-induced right ventricular failure? Listen to find out.
Sachindra Raj Joshi, Vidhi Dhagia, Salina Gairhe, John G. Edwards, Ivan F. McMurtry, Sachin A Gupte MicroRNA-140 is elevated and mitofusin-1 is downregulated in the right ventricle of the Sugen5416/Hypoxia/Normoxia model of pulmonary arterial hypertension Am J Physiol Heart Circ Physiol, published July 15, 2016. DOI: 10.1152/ajpheart.00264.2016
More Episodes
2020-06-15
294
2020-05-29
321
2020-05-25
337
2020-05-22
377
2020-05-22
184
2020-05-07
290
2020-04-30
716
2020-04-27
239
2020-02-11
423
2019-12-20
672
2019-12-11
363
2019-12-10
290
2019-11-19
441
2019-11-07
371
2019-09-05
382
2019-08-21
350
2019-08-14
303
2019-08-07
340
Get this podcast on your
phone, FREE
