miR140 and Right Heart Hypertrophy

Is there one microRNA playing a primary role in the complex pathogenesis of right ventricular failure caused by pulmonary hypertension? Listen as Associate Editor Fabio Recchia (Temple University Lewis Katz School of Medicine, and Scuola Superiore Sant'Anna, Pisa, Italy) interviews lead author Sachin Gupte (New York Medical College) and content expert Paras Mishra (University of Nebraska Medical Center) about the work by Joshi et al, which used microarray analysis to focus on MiR140 as a potential therapeutic target in a Sugen5416/hypoxia/normoxia model of pulmonary arterial hypertension (PAH). Is MiR31 also a major player in the pathogenesis of this disease? What is the translational relevance of the work by Gupte and colleagues on afterload-induced right ventricular failure? Listen to find out.

Sachindra Raj Joshi, Vidhi Dhagia, Salina Gairhe, John G. Edwards, Ivan F. McMurtry, Sachin A Gupte MicroRNA-140 is elevated and mitofusin-1 is downregulated in the right ventricle of the Sugen5416/Hypoxia/Normoxia model of pulmonary arterial hypertension Am J Physiol Heart Circ Physiol, published July 15, 2016. DOI: 10.1152/ajpheart.00264.2016