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About This Episode:
The Sydney Diet-Heart Study was a clinical trial conducted in the 1960s and 1970s that aimed to examine the hypothesis that reducing saturated fat intake in the diet would lead to a reduced risk of heart disease.
However, it really only gained attention after a more recent re-analysis by Ramsden et al., which in recent years has been used as supporting evidence for the idea that increased polyunsaturated fat (PUFA), and specifically linoleic acid, in addition to reduced saturated fat intake, can increase heart disease risk.
This was based on the findings that substituting linoleic acid in place of saturated fat increased all-cause, CVD and CHD mortality.
This is of course counter to prevailing consensus and guidelines in this area, which routinely show reduced risk on replacing SFA with PUFA.
Could this trial undermine the common conclusions that replacing saturated fat with polyunsaturated fat decreases heart disease risk?
In this episode Alan and Danny discuss some of the crucial aspects to understand about this study and what it means for what conclusions can be made about the impact of PUFA broadly, and linoleic acid specifically, on our health.
#333: Diet & Immunity
#332: Prof. Sam McConkey – COVID-19: Public Health Response, Clinical Presentation & Socioeconomics
#331: Prof. Roy Taylor – Diabetes Remission, Very-low Calorie Diets & the Twin Cycle Hypothesis
#330: Eric Trexler, PhD – Antioxidants, Oxidative Stress & Exercise Adaptations
#329: Diet & Inflammation
#328: Meeta Singh, MD – Sleep, Immunity & Mental Health
#327: David Dunne – Behavioural Science in Nutrition
#326: Krista Scott-Dixon, PhD – Adaptability & Autonomy in the Nutrition Coaching Process
#325: Kirk Parsley, MD - Stress, Sleep & Anxiety During a Pandemic
#324: Fatima Cody Stanford, MD – Obesity Treatment & Weight Bias
#323: COVID-19 & SARS-CoV-2 with Rizwan Sohail, MD
#322: Dominic Munnelly – Coaching People To Health: Philosophy, Empathy & Community
#321: Dave Feldman & Alan Flanagan – Debating LDL Causality & the “Lipid Triad”
#320: Hannah Ritchie, PhD – Environmental Impacts of our Diet: Climate, Carbon Footprint & Land Use
#319: Women in Science: Past Guests as Role Models in Nutrition
#318: Chris Melby, PhD – Impact of Energy Flux on Weight Loss Maintenance
#317: Understanding Diet & Heart Disease Risk
#316: Michael Grandner, PhD – Societal, Social & Psychological Influences on Sleep
#315: Samia Mora, MD – Lipids, Lipoproteins & Atherosclerosis
#314: Q&A – Hemochromatosis, Sodium, Bone Health, & More!
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