In this episode:
00:46 A virtual chemical library uncovers potential antidepressants
Certain psychedelic drugs are of interest to researchers due to their promising antidepressant effects. To help speed up the discovery of molecules with useful properties, researchers have built a virtual library of 75 million compounds related to these drugs. This approach yielded two molecules that showed antidepressant properties in mice, but without the hallucinogenic activity of psychedelic drugs.
Research article: Kaplan et al.
Research Briefing: Bespoke library docking for 5-HT2A receptor agonists with antidepressant activity
08:25 Research Highlights
Research suggests that ancient artificial island settlements were hubs of activity for society’s elite, and astronomers spot possibly the most luminous star ever observed.
Research Highlight: Ancient DNA suggests that artificial islands were party spots for the elite
Research Highlight: Scientists face down ‘Godzilla’, the most luminous star known
10:42 Nobel News
Flora Graham from the Nature Briefing joins us to talk about the winners of this year’s Nobel Prizes.
Nature News: Geneticist who unmasked lives of ancient humans wins medicine Nobel
Nature News: ‘Spooky’ quantum-entanglement experiments win physics Nobel
Nature News: Chemists who invented revolutionary 'click' reactions win Nobel
Enter Nature’s ‘Scientist at Work’ photo competition, full details here
Subscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday.
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Physicists finally observe strange isotope Oxygen 28 – raising fundamental questions
Audio long read: Medicine is plagued by untrustworthy clinical trials. How many studies are faked or flawed?
Brain-reading implants turn thoughts into speech
Fruit flies' ability to sense magnetic fields thrown into doubt
Racism in health: the roots of the US Black maternal mortality crisis
How welcome are refugees in Europe? A giant study has some answers
How to get more women in science, with Athene Donald
Audio long read: Lab mice go wild — making experiments more natural in order to decode the brain
Facebook ‘echo chamber’ has little impact on polarized views, according to study
AI-enhanced night-vision lets users see in the dark
Disrupting snail food-chain curbs parasitic disease in Senegal
ChatGPT can write a paper in an hour — but there are downsides
Even a 'minimal cell' can grow stronger, thanks to evolution
Audio long read: ‘Almost magical’ — chemists can now move single atoms in and out of a molecule’s core
Do octopuses dream? Neural activity resembles human sleep stages
Why bladder cancer cells that shed their Y chromosome become more aggressive
What IBM's result means for quantum computing
A brain circuit for infanticide, in mice
AI identifies gene interactions to speed up search for treatment targets
Audio long read: Can giant surveys of scientists fight misinformation on COVID, climate change and more?
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