In this episode:
00:46 A virtual chemical library uncovers potential antidepressants
Certain psychedelic drugs are of interest to researchers due to their promising antidepressant effects. To help speed up the discovery of molecules with useful properties, researchers have built a virtual library of 75 million compounds related to these drugs. This approach yielded two molecules that showed antidepressant properties in mice, but without the hallucinogenic activity of psychedelic drugs.
Research article: Kaplan et al.
Research Briefing: Bespoke library docking for 5-HT2A receptor agonists with antidepressant activity
08:25 Research Highlights
Research suggests that ancient artificial island settlements were hubs of activity for society’s elite, and astronomers spot possibly the most luminous star ever observed.
Research Highlight: Ancient DNA suggests that artificial islands were party spots for the elite
Research Highlight: Scientists face down ‘Godzilla’, the most luminous star known
10:42 Nobel News
Flora Graham from the Nature Briefing joins us to talk about the winners of this year’s Nobel Prizes.
Nature News: Geneticist who unmasked lives of ancient humans wins medicine Nobel
Nature News: ‘Spooky’ quantum-entanglement experiments win physics Nobel
Nature News: Chemists who invented revolutionary 'click' reactions win Nobel
Enter Nature’s ‘Scientist at Work’ photo competition, full details here
Subscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday.
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JWST shows an ancient galaxy in stunning spectroscopic detail
Nature's Take: Can Registered Reports help tackle publication bias?
‘Pangenome’ aims to capture the breadth of human diversity
Menopause and women’s health: why science needs to catch up
Audio long read: Conquering Alzheimer’s — a look at the therapies of the future
How Rosalind Franklin’s story was rewritten
A smarter way to melt down plastics?
How to battle misinformation with Sander van der Linden
Octopuses hunt by 'tasting' with their suckers
Giant black-hole pair from the early Universe gives clues to how galaxies form
Audio long read: What Turkey’s earthquake tells us about the science of seismic forecasting
Bacterial ‘syringes’ could inject drugs directly into human cells
How to make driverless cars safer — expose them to lots of dangerous drivers
How to build a virus-proof cell
How the Australian wildfires devastated the ozone layer
How an increased heart rate could induce anxiety in mice
Nature's Take: How Twitter's changes could affect science
Audio long read: How your first brush with COVID warps your immunity
A twisting microscope that could unlock the secrets of 2D materials
How 'metadevices' could make electronics faster
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