Question: What cofactors are needed to synthesize and recycle BH4?
Short Answer: Zinc, magnesium, potassium, and niacin are the cofactors needed for the synthesis and recycling of BH4. Folate and methylation are not involved, though high-dose folate or folic acid could hypothetically hurt BH4 recycling since both are recycled by dihydrofolate reductase (DHFR).
This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link:
https://chrismasterjohnphd.substack.com/p/questions-on-vitamin-d-sulfate-synthesis
In that batch of free episodes you will also find the answers to these questions:
Is It Important to Get Vitamin D Sulfate Specifically From the Sun?
How Much Iron Can We Absorb At Once?
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This snippet is from the February 15, 2023 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what’s included:
Is It Important to Get Vitamin D Sulfate Specifically From the Sun?
How Much Iron Can We Absorb At Once?
What nutrients are important for long-term PPI use?
For how long does transferrin saturation respond to recent iron-rich food?
Muscle spasms: creatine, creatinine, sodium, and potassium.
Hematologists ignore iron saturation.
How to detox arsenic?
Could folic acid supplements impair BH4 recycling?
How to increase butyrate?
More on hematologists and transferrin saturation.
Here’s a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-february
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Why Would Citrate or Malate Cause Insomnia?
What to Do About Constipation
How to slow or reverse graying of hair? | Masterjohn Q&A Files #321
How Much Iron Can We Absorb At Once? | Masterjohn Q&A Files #320
Is It Important to Get Vitamin D Sulfate Specifically From the Sun? | Masterjohn Q&A Files #318
When to Consider Inborn Errors of Metabolism
How to Recover From Fish Oil
Can B12 and Folate Help Detoxify Oxalate?
If I have a hereditary weakness in breaking down branched-chain amino acids, what cofactors do I need to consider, and do I need to restrict my protein when losing weight? | Masterjohn Q&A Files #317
How do I consume omega-3 without hurting my omega-6 status? | Masterjohn Q&A Files #316
Energy Metabolism Governs Everything
Can plant foods and their phytochemicals be used to reduce arterial plaque? | Masterjohn Q&A Files #315
What to Do About Twitching | Masterjohn Q&A Files #314
Can Biotin Help Detoxify Oxalate?
Vitamin K2 and Undercarboxylated Osteocalcin | Masterjohn Q&A Files #313
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