Question: What cofactors are needed to synthesize and recycle BH4?
Short Answer: Zinc, magnesium, potassium, and niacin are the cofactors needed for the synthesis and recycling of BH4. Folate and methylation are not involved, though high-dose folate or folic acid could hypothetically hurt BH4 recycling since both are recycled by dihydrofolate reductase (DHFR).
This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link:
https://chrismasterjohnphd.substack.com/p/questions-on-vitamin-d-sulfate-synthesis
In that batch of free episodes you will also find the answers to these questions:
Is It Important to Get Vitamin D Sulfate Specifically From the Sun?
How Much Iron Can We Absorb At Once?
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https://chrismasterjohnphd.substack.com/qanda
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This snippet is from the February 15, 2023 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what’s included:
Is It Important to Get Vitamin D Sulfate Specifically From the Sun?
How Much Iron Can We Absorb At Once?
What nutrients are important for long-term PPI use?
For how long does transferrin saturation respond to recent iron-rich food?
Muscle spasms: creatine, creatinine, sodium, and potassium.
Hematologists ignore iron saturation.
How to detox arsenic?
Could folic acid supplements impair BH4 recycling?
How to increase butyrate?
More on hematologists and transferrin saturation.
Here’s a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-february
Nutrition For Bone Healing | Masterjohn Q&A Files #269
What tests to use for protein status? | Masterjohn Q&A Files #268
Is nicotinamide riboside hydrogen malate as good as NR for fasting? | Masterjohn Q&A Files #267
Would high-dose thiamin cause imbalances with other B vitamins? | Masterjohn Q&A Files #266
Why does B12 damaged by nitrous oxide require megadosed folic acid rather than normal levels of folate? | Masterjohn Q&A Files #265
Nutrition, Metformin, and Respiratory Chain Disorders | Masterjohn Q&A Files #264
Why do some paleo advocates and functional medicine practitioners recommend low-calcium diets? | Masterjohn Q&A Files #263
How should you program the temperature on an Ooler or Eight Sleep? | Masterjohn Q&A Files #262
Is it useful to measure HVA, VMA, and 5-HIAA? | Masterjohn Q&A Files #261
What nutrients require insulin to get into cells? | Masterjohn Q&A Files #260
What are the top whole food supplements to take? | Masterjohn Q&A Files #259
Could iron deficiency create a complex 1 disorder? | Masterjohn Q&A Files #258
How to get more sulfate if you have sulfite issues? | Masterjohn Q&A Files #257
If you're eating oysters, do you need to eat liver too? | Masterjohn Q&A Files #256
Lipoic acid: does it need to be the R form? | Masterjohn Q&A Files #255
How much fruit is it safe to eat at once? | Masterjohn Q&A Files #254
Should I supplement NAC if cysteine, taurine, and sulfate are low? | Masterjohn Q&A Files #253
Iron deficiency without anemia? | Masterjohn Q&A Files #252
How to Calculate the Amount of a Nutrient in a Complex | Masterjohn Q&A Files #251
Eggs, Choline Bisulfate, and TMAO | Masterjohn Q&A Files #250
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