In this “Ask Me Anything” (AMA) episode, Peter and Bob discuss all things related to testosterone: what happens when testosterone levels are low, and the potential benefits and risks of testosterone replacement therapy (TRT). They explain the physiology of testosterone, how it works, and how its level changes over the course of a person's life. They have a detailed discussion about existing literature, which reveals vast potential structural, functional, and metabolic benefits of testosterone replacement therapy. They also take a very close look at potential risks of this therapy, with a focus on the controversial effects on cardiovascular disease and prostate cancer.
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We discuss:
#157 - AMA #22: Losing fat and gaining fat: the lessons of fat flux
#156 - Jake Muise: Humanely harvesting axis deer while alleviating its impact on Hawaii’s vulnerable ecosystems
#155 - Chris Sonnenday, M.D.: The history, challenges, and gift of organ transplantation
#154 - Steve Levitt, Ph.D.: A rogue economist’s view on climate change, mental health, the ethics of experiments, and more
#153 - AMA #21: Deep dive into olive oil, high-intensity exercise, book update, and more
#152 - Michael Rintala, D.C.: Principles of Dynamic Neuromuscular Stabilization (DNS)
#151 - Alex Hutchinson, Ph.D.: Translating the science of endurance and extreme human performance
#150 - Senator Bill Frist, M.D.: A modern Renaissance man's journey through science, politics, and business
#149 - AMA #20: Simplifying the complexities of insulin resistance: how it's measured, how it manifests in the muscle and liver, and what we can do about it
#148 - Richard Miller, M.D., Ph.D.: The gold standard for testing longevity drugs: the Interventions Testing Program
#147 - Hussein Yassine, M.D.: Deep dive into the “Alzheimer’s gene” (APOE), brain health, and omega-3s
#146 - Guy Winch, Ph.D.: Emotional first aid and how to treat psychological injuries
#145 - AMA #19: Deep dive on Zone 2 training, magnesium supplementation, and how to engage with your doctor
#144 - Phil Maffetone: Optimizing health and performance through maximal aerobic function
#143 - John Ioannidis, M.D., D.Sc.: Why most biomedical research is flawed, and how to improve it
#142 - Robert Abbott: The Bobby Knight story—a cautionary tale of unchecked anger, ego, and winning at all costs
#141 - AMA #18: Deep dive: sugar and sugar substitutes
#140 - Gerald Shulman, M.D., Ph.D.: A masterclass on insulin resistance—molecular mechanisms and clinical implications
#139 - Kristin Neff, Ph.D.: The power of self-compassion
#138 - Lauren Miller Rogen and Richard Isaacson, M.D.: Alzheimer’s disease prevention—patient and doctor perspectives
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