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BTBA presents: 生技來一刻

BTBA presents: 生技來一刻

Technology

RNA 干擾療法 ft. 杜荷洲 Dr. Ho-Chou Tu

RNA 干擾療法 ft. 杜荷洲 Dr. Ho-Chou Tu

2023-03-15
Download

RNA 干擾 (RNAi) 機制於 2006 年獲得諾貝爾生理或醫學獎,成為當時當紅的新興潛力藥物平台,然而早期的 RNA 干擾藥物開發連連失利,連藥廠巨人們都紛紛退出這個領域。 2018 年,Alnylam Pharmaceuticals 終於通過第一支 RNA 干擾藥物,並在短短幾年內陸續推出多款成功藥物,RNA 干擾療法又重新成為眾人的關注焦點。本集生技來一刻邀請到在 Alnylam 任職的杜荷洲博士,為我們介紹 RNA 干擾機制以及相關藥物開發,我們也談了這將近二十年 Alnylam 打關的種種難關,如何匯聚業界研究、基礎研究、多方專業的努力來共同推動 RNA 干擾藥物的問世。

 

生技來一刻感謝國科會與駐波士頓辦事處科技組贊助我們製作節目。我們也歡迎聽眾小額捐款生技來一刻,您的支持能幫助我們製作更優質的節目。

 

BTBA Facebook 專頁:https://www.facebook.com/btbatw 

👩‍💻 杜荷洲 Dr. Ho-Chou Tu:https://www.linkedin.com/in/ho-chou-tu/

🎤 主持人 | 陳乃群:https://www.linkedin.com/in/ncchen/

👩‍💻 後製 | 陳君瑋:https://www.linkedin.com/in/chun-wei-chen-b28813195/

 

🎧  立即收聽 Podcasts 🎧

Apple Podcasts: https://tinyurl.com/y6gwcke4 

Google Podcasts: https://tinyurl.com/y256lv6y  

Spotify: https://tinyurl.com/y6sz5wno 

SoundOn: https://tinyurl.com/y32zrmhf 

BTBA Podcast 專頁:http://btbatw.org/podcast 

 

讓我們也一起回顧一下過去相關訪問:

  • 「藥物製程專題 (二)-核酸藥物 ft. 朱治齊博士」https://tmrbiotechmoments.podbean.com/e/jimmy-chu/
  • 罕見疾病的個人化療法 ft. 游維文 (Dr. Timothy Yu) https://tmrbiotechmoments.podbean.com/e/timothyyu/
  • 基因編輯療法與罕見疾病 ft. 閔譯立 (Dr. Yi-Li Min) https://tmrbiotechmoments.podbean.com/e/yi-li-min/
  • 千里之行,始於足下—新藥研發的第一步:標的確認 ft. Shian-Huey Chiang https://tmrbiotechmoments.podbean.com/e/shian-huey-chiang/

時間軸

  • 講者介紹 (00:30)
  • 加入 Alnylam 的時機、跟著公司成長 (7:05)
  • RNA 干擾介紹 (10:15)
  • 為什麼開發 RNA 干擾藥物花了將近 20 年? (14:19)
  • 基礎研究的重要性 (24:14)
  • 為什麼許多 RNA 干擾藥物都是輸送到肝臟? (25:43)
  • 早期的藥物開發策略 (27:45)
  • RNA 干擾療法的好處 (35:43)
  • 在公司的角色的變化 (40:58)
  • 遺傳學研究發表 (47:30)
  • 公司文化以及中階主管的角色 (51:53)
  • 帶領團隊的方式 (58:15)
  • 當初可以做得更好的事情 (1:01:00)
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