Timestamps:
0:00 – intro
0:33 – why we started this podcast
6:25 – our take on Bryan Johnson’s Longevity Blueprint and problems with biohacking
12:13 – whether we should adopt any of the strategies from Bryan Johnson’s Blueprint to achieve optimal health
14:50 – the cost of continually being in a caloric deficit and why this does not increase longevity
21:06 – issues with eating hard-to-digest foods and whether supplements can make up for missing nutrients in the diet
22:13 – the importance of avoiding reductionistic thinking around supplements touted for weight loss benefits
28:00 – potential pros and cons of Bryan Johnson’s Blueprint and how to measure health
32:39 – Bryan Johnson’s supplement protocol
41:09 – how low-carb diets negatively affect NAD+ to NADH ratios and estrogen status
46:20 – whether body fat percentage and cholesterol levels can be too low
52:20 – what is stress?
1:03:20 – issues with hormesis and the idea that stress is beneficial
1:07:34 – whether avoiding stress is possible and how to develop resilience to stress
1:13:17 – addressing Marty Kendall’s response to our take on glucagon and insulin
1:24:17 – glucagon’s short-term and long-term effects on metabolic function
1:26:46 – glucagon’s role in insulin resistance and type 2 diabetes
1:37:16 – metabolic dysfunction as a driver of insulin resistance
1:41:06 – whether we need to be concerned about wasting energy on hormone production
1:44:50 – whether we should always try to avoid gluconeogenesis
1:51:45 – how to use carbohydrates to stabilize your blood sugar
1:56:11 – habit stacking, simplifying supplementation, and adopting a long-term mindset when it comes to health
